Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure

Preston Izulla; Lyle R. McKinnon; Julius Munyao; Naomi Ireri; Nico Nagelkerke; Gloria Gakii; Lawrence Gelmon; Mabel Nangami; Rupert Kaul; Joshua Kimani

doi:10.1007/s10461-015-1091-1

Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure

Preston Izulla, Lyle R. McKinnon, Julius Munyao, Naomi Ireri, Nico Nagelkerke, Gloria Gakii, Lawrence Gelmon, Mabel Nangami, Rupert Kaul, Joshua Kimani

Department of Public Health Institute

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis (PEP) access in the context of a large FSW program in Nairobi. During close to 6000 person-years of follow-up, 20 % of participants (n = 1119) requested PEP at least once and 3.7 % requested PEP more than once. Repeat PEP users were younger, had a higher casual partner volume, and were more likely to use condoms with casual and regular partners, have a regular partner, and test for HIV prior to enrolment. Barriers to PEP included stigma, side effects, and lack of knowledge, suggesting repeated promotion may be required for higher rates of uptake. A small subset of FSW, potentially those with heightened risk perception, showed a higher frequency of PEP use; these individuals may be most amenable to rollout of pre-exposure prophylaxis.

Original language	English
Pages (from-to)	1549-1555
Number of pages	7
Journal	AIDS and Behavior
Volume	20
Issue number	7
DOIs	https://doi.org/10.1007/s10461-015-1091-1
Publication status	Published - Jul 1 2016

Keywords

FSW
HIV prevention
PEP
PrEP
Risk perception

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-015-1091-1

Cite this

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title = "Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure",

abstract = "As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis (PEP) access in the context of a large FSW program in Nairobi. During close to 6000 person-years of follow-up, 20 % of participants (n = 1119) requested PEP at least once and 3.7 % requested PEP more than once. Repeat PEP users were younger, had a higher casual partner volume, and were more likely to use condoms with casual and regular partners, have a regular partner, and test for HIV prior to enrolment. Barriers to PEP included stigma, side effects, and lack of knowledge, suggesting repeated promotion may be required for higher rates of uptake. A small subset of FSW, potentially those with heightened risk perception, showed a higher frequency of PEP use; these individuals may be most amenable to rollout of pre-exposure prophylaxis.",

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author = "Preston Izulla and McKinnon, {Lyle R.} and Julius Munyao and Naomi Ireri and Nico Nagelkerke and Gloria Gakii and Lawrence Gelmon and Mabel Nangami and Rupert Kaul and Joshua Kimani",

note = "Funding Information: We would like to acknowledge and thank all the staff and participants of the SWOP clinic in Nairobi for their assistance with the completion of this study. Funding was provided by US-PEPFAR (CDC-PEPFAR U62/CCU024510-01) to L.G. and J.K. and CIHR MOP-89983 to R.K. R.K. is supported by an OHTN Career Scientist Award. L.R.M. was supported by a CIHR fellowship and the International Infectious Diseases and Global Health Training Program. Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York.",

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AU - Nagelkerke, Nico

AU - Gakii, Gloria

AU - Gelmon, Lawrence

AU - Nangami, Mabel

AU - Kaul, Rupert

AU - Kimani, Joshua

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PY - 2016/7/1

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N2 - As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis (PEP) access in the context of a large FSW program in Nairobi. During close to 6000 person-years of follow-up, 20 % of participants (n = 1119) requested PEP at least once and 3.7 % requested PEP more than once. Repeat PEP users were younger, had a higher casual partner volume, and were more likely to use condoms with casual and regular partners, have a regular partner, and test for HIV prior to enrolment. Barriers to PEP included stigma, side effects, and lack of knowledge, suggesting repeated promotion may be required for higher rates of uptake. A small subset of FSW, potentially those with heightened risk perception, showed a higher frequency of PEP use; these individuals may be most amenable to rollout of pre-exposure prophylaxis.

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Repeat Use of Post-exposure Prophylaxis for HIV Among Nairobi-Based Female Sex Workers Following Sexual Exposure

Abstract

Keywords

ASJC Scopus subject areas

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