Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice

Ahmed R. Alsuwaidi, Alia Albawardi, Saeeda Almarzooqi, Sheela Benedict, Aws R. Othman, Stacey M. Hartwig, Steven M. Varga, Abdul Kader Souid

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We have previously reported that lung cellular bioenergetics (cellular respiration and ATP) increased in 4-10 week-old BALB/c mice infected with respiratory syncytial virus (RSV). This study examined the kinetics and changes in cellular bioenergetics in ≤2-week-old C57BL/6 mice following RSV infection. Mice (5-14 days old) were inoculated intranasally with RSV and the lungs were examined on days 1-10 post-infection. Histopathology and electron microscopy revealed preserved pneumocyte architectures and organelles. Increased lung cellular bioenergetics was noted from days 1-10 post-infection. Cellular GSH remained unchanged. These results indicate that the increased lung cellular respiration (measured by mitochondrial O2 consumption) and ATP following RSV infection is independent of either age or genetic background of the host.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
Issue number1
Publication statusPublished - Apr 2014


  • C57BL/6
  • Cellular ATP
  • Cellular respiration
  • Mice
  • Mitochondria
  • Neonates
  • Oxygen consumption
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Virology


Dive into the research topics of 'Respiratory syncytial virus increases lung cellular bioenergetics in neonatal C57BL/6 mice'. Together they form a unique fingerprint.

Cite this