Revolutionizing personalized medicine with generative AI: a systematic review

Isaias Ghebrehiwet, Nazar Zaki, Rafat Damseh, Mohd Saberi Mohamad

Research output: Contribution to journalArticlepeer-review


Background: Precision medicine, targeting treatments to individual genetic and clinical profiles, faces challenges in data collection, costs, and privacy. Generative AI offers a promising solution by creating realistic, privacy-preserving patient data, potentially revolutionizing patient-centric healthcare. Objective: This review examines the role of deep generative models (DGMs) in clinical informatics, medical imaging, bioinformatics, and early diagnostics, showcasing their impact on precision medicine. Methods: Adhering to PRISMA guidelines, the review analyzes studies from databases such as Scopus and PubMed, focusing on AI's impact in precision medicine and DGMs' applications in synthetic data generation. Results: DGMs, particularly Generative Adversarial Networks (GANs), have improved synthetic data generation, enhancing accuracy and privacy. However, limitations exist, especially in the accuracy of foundation models like Large Language Models (LLMs) in digital diagnostics. Conclusion: Overcoming data scarcity and ensuring realistic, privacy-safe synthetic data generation are crucial for advancing personalized medicine. Further development of LLMs is essential for improving diagnostic precision. The application of generative AI in personalized medicine is emerging, highlighting the need for more interdisciplinary research to advance this field.

Original languageEnglish
Article number128
JournalArtificial Intelligence Review
Issue number5
Publication statusPublished - May 2024


  • Artificial Intelligence
  • Chat Generative Pre-Trained Transformer (ChatGPT)
  • Deep Generative Models (DGMs)
  • Foundation Models (FM)
  • Generative Adversarial Networks (GANs)
  • Generative AI
  • Individualized Treatment Effect (ITE)
  • Large Language Models (LLMs)
  • Personalized Medicine
  • Personalized treatment
  • Precision Medicine

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Artificial Intelligence


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