TY - JOUR
T1 - Right ventricular dysfunction in hypertrophic cardiomyopathy as evidenced by the myocardial performance index
AU - Mörner, Stellan
AU - Lindqvist, Per
AU - Waldenström, Anders
AU - Kazzam, Elsadig
N1 - Funding Information:
This study was supported by The Swedish Heart and Lung Foundation, The Medical Faculty at Umeå University, The Heart Foundation of Northern Sweden and The Swedish Society of Medicine.
PY - 2008/2/20
Y1 - 2008/2/20
N2 - Background: Left ventricular function in hypertrophic cardiomyopathy (HCM) has been extensively studied, whereas right ventricular function is much less explored. The myocardial performance index (MPI) has been shown to be useful in functional assessment of both ventricles. Furthermore, right ventricular MPI was found to be of predictive value in heart failure due to dilated cardiomyopathy and ischemic heart disease. The aim of this study was, therefore, to evaluate the right ventricular MPI in patients with HCM. Methods: Fifty patients with HCM and 250 healthy controls were studied by conventional Doppler echocardiography and Doppler tissue imaging. Results: Patients showed increased global, 0.48 (0.15) vs. 0.21 (0.14), and regional, 0.71 (0.23) vs. 0.55 (0.17), right ventricular MPI, as compared to controls, p < 0.001. Tricuspid annular plane systolic excursion and peak myocardial systolic velocities were also reduced. Patients with dyspnoea had increased global right ventricular MPI (0.53 vs. 0.36, p < 0.05) as compared to those without dyspnoea. Conclusion: In the present study, patients with HCM showed evidence of both global and regional right ventricular dysfunction. Previous studies of the right ventricle in HCM have only shown evidence of diastolic dysfunction, contrary to our results, showing impairment of both systolic and diastolic function. This study suggests that HCM should not only be regarded as an isolated disease of the left ventricle, but rather as a biventricular disease. The predictive value of our findings in HCM needs to be assessed in a separate study with special reference to those with and without dyspnoea.
AB - Background: Left ventricular function in hypertrophic cardiomyopathy (HCM) has been extensively studied, whereas right ventricular function is much less explored. The myocardial performance index (MPI) has been shown to be useful in functional assessment of both ventricles. Furthermore, right ventricular MPI was found to be of predictive value in heart failure due to dilated cardiomyopathy and ischemic heart disease. The aim of this study was, therefore, to evaluate the right ventricular MPI in patients with HCM. Methods: Fifty patients with HCM and 250 healthy controls were studied by conventional Doppler echocardiography and Doppler tissue imaging. Results: Patients showed increased global, 0.48 (0.15) vs. 0.21 (0.14), and regional, 0.71 (0.23) vs. 0.55 (0.17), right ventricular MPI, as compared to controls, p < 0.001. Tricuspid annular plane systolic excursion and peak myocardial systolic velocities were also reduced. Patients with dyspnoea had increased global right ventricular MPI (0.53 vs. 0.36, p < 0.05) as compared to those without dyspnoea. Conclusion: In the present study, patients with HCM showed evidence of both global and regional right ventricular dysfunction. Previous studies of the right ventricle in HCM have only shown evidence of diastolic dysfunction, contrary to our results, showing impairment of both systolic and diastolic function. This study suggests that HCM should not only be regarded as an isolated disease of the left ventricle, but rather as a biventricular disease. The predictive value of our findings in HCM needs to be assessed in a separate study with special reference to those with and without dyspnoea.
KW - Doppler tissue imaging
KW - Echocardiography
KW - Hypertrophic cardiomyopathy
KW - Myocardial performance index
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U2 - 10.1016/j.ijcard.2006.12.022
DO - 10.1016/j.ijcard.2006.12.022
M3 - Article
C2 - 17383757
AN - SCOPUS:38149122103
SN - 0167-5273
VL - 124
SP - 57
EP - 63
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -