Risk of cutaneous squamous cell carcinoma due to occupational exposure to solar ultraviolet radiation: Protocol for a systematic review and meta-analysis

Marília Silva Paulo, Cara Symanzik, Balázs Ádam, Fabriziomaria Gobba, Sanja Kezic, Henk F. van der Molen, Cheryl E. Peters, Marc Rocholl, Thomas Tenkate, Swen Malte John, Tom Loney, Alberto Modenese, Marc Wittlich

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Solar ultraviolet radiation (UVR) is the most significant occupational carcinogenic exposure in terms of the number of workers exposed (i.e., outdoor workers). Consequently, solar UVR-induced skin cancers are among the most common forms of occupational malignancies that are potentially expected globally. This systematic review is registered in PROSPERO (CRD42021295221) and aims to assess the risk of cutaneous squamous cell carcinoma (cSCC) associated to occupational solar UVR exposure. Systematic searches will be performed in three electronic literature databases (PubMed/Medline, EMBASE, and Scopus). Further references will be retrieved by a manual search (e.g., in grey literature databases, internet search engines, and organizational websites). We will include cohort studies and case-control studies. Risk of Bias assessment will be conducted separately for case-control and cohort studies. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) will be used for the certainty of assessment. In case quantitative pooling is not feasible, a narrative synthesis of results will be performed.

Original languageEnglish
Article numbere0282664
JournalPLoS ONE
Volume18
Issue number3 March
DOIs
Publication statusPublished - Mar 2023

ASJC Scopus subject areas

  • General

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