Role of Neuroinflammation in Autism Spectrum Disorder and the Emergence of Brain Histaminergic System. Lessons Also for BPSD?

Nermin Eissa, Adel Sadeq, Astrid Sasse, Bassem Sadek

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

Many behavioral and psychological symptoms of dementia (BPSD) share similarities in executive functioning and communication deficits with those described in several neuropsychiatric disorders, including Alzheimer’s disease (AD), epilepsy, schizophrenia (SCH), and autism spectrum disorder (ASD). Numerous studies over the last four decades have documented altered neuroinflammation among individuals diagnosed with ASD. The purpose of this review is to examine the hypothesis that central histamine (HA) plays a significant role in the regulation of neuroinflammatory processes of microglia functions in numerous neuropsychiatric diseases, i.e., ASD, AD, SCH, and BPSD. In addition, this review summarizes the latest preclinical and clinical results that support the relevance of histamine H1-, H2-, and H3-receptor antagonists for the potential clinical use in ASD, SCH, AD, epilepsy, and BPSD, based on the substantial symptomatic overlap between these disorders with regards to cognitive dysfunction. The review focuses on the histaminergic neurotransmission as relevant in these brain disorders, as well as the effects of a variety of H3R antagonists in animal models and in clinical studies.

Original languageEnglish
Article number886
JournalFrontiers in Pharmacology
Volume11
DOIs
Publication statusPublished - Jun 16 2020

Keywords

  • Alzheimer’s disease
  • H3R antagonists
  • autism spectrum disorder
  • behavioral and psychological symptoms of dementia
  • central histamine receptors
  • cytokines
  • neuroinflammation
  • schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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