Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs

Fikri M. Abu-Zidan, Sten Walther, Sten Lennquist

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Objectives: To study the role of platelet-activating factor (PAF) antagonism in posthemorrhage septic shock in pigs. Design: Experimental study. Materials and Methods: Twelve anesthetized pigs were bled, kept with a mean arterial pressure of 30 mm Hg for 30 minutes, and then resuscitated with 50 mL/kg of isotonic saline. A continuous infusion of Escherichia coli endotoxin 36 μg/kg/hour was given intravenously for 3.5 hours starting 30 minutes after resuscitation. The animals were divided into two groups of six each. One group received 1 mg/kg of BB-882 (a potent specific PAF receptor antagonist) as a bolus during resuscitation, followed by a continuous infusion of BB-882 1 mg/kg/hour. The other group received vehicle alone. Measurements and Main Results: The measured variables were blood temperature, heart rate, intravascular pressures, cardiac output, systemic and pulmonary vascular resistance, lung-thorax compliance, blond gases, hemoglobin oxygen saturation, packed cell volume, and blood sugar and serum lactic acid concentrations. The group treated with BB-882 had significantly higher intracardiac pressures and cardiac output, and had less increase in systemic vascular resistance. The BB-882 group had significantly less lactic acidemia than the control group (p < 0.05, analysis of variance appropriate fur repeated measurement design). BB-882 had no effect on endotoxin-induced hypoxia or reduced lung-thorax compliance. Conclusions: PAF antagonism reduced the increase in systemic vascular resistance, improved cardiac output, and reduced lactic acidemia in posthemorrhage septic shock in pigs, but it did not improve hypoxia or reduced lung-thorax compliance.

Original languageEnglish
Pages (from-to)634-640
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number4
Publication statusPublished - Oct 1996
Externally publishedYes


  • Endotoxin
  • Hemorrhage
  • Platelet-activating factor antagonist
  • Shock

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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