Role of the calcium store in uterine contractility

Susan Wray; Anatoly Shmygol

doi:10.1016/j.semcdb.2007.05.005

Role of the calcium store in uterine contractility

Susan Wray, Anatoly Shmygol

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

This article assesses the nature of the sarcoplasmic reticulum (SR) in uterine smooth muscle. Modern imagining techniques have revealed new information about the location and density of Ca storage and release. Release mechanisms, including IP₃ and Ca itself, via ryanodine receptors (RyR), as well as possible roles for cyclic ADP ribose, and the contribution of the SR to relaxation are detailed. The role of the SR Ca-ATPase in both decay of the Ca transient and maintaining Ca homeostasis is reviewed. Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains.

Original language	English
Pages (from-to)	315-320
Number of pages	6
Journal	Seminars in Cell and Developmental Biology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.semcdb.2007.05.005
Publication status	Published - Jun 2007
Externally published	Yes

Keywords

Calcium sparks
Contraction
Myometrium
Sarcoplasmic reticulum
Signalling

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2007.05.005

Cite this

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title = "Role of the calcium store in uterine contractility",

abstract = "This article assesses the nature of the sarcoplasmic reticulum (SR) in uterine smooth muscle. Modern imagining techniques have revealed new information about the location and density of Ca storage and release. Release mechanisms, including IP3 and Ca itself, via ryanodine receptors (RyR), as well as possible roles for cyclic ADP ribose, and the contribution of the SR to relaxation are detailed. The role of the SR Ca-ATPase in both decay of the Ca transient and maintaining Ca homeostasis is reviewed. Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains.",

keywords = "Calcium sparks, Contraction, Myometrium, Sarcoplasmic reticulum, Signalling",

author = "Susan Wray and Anatoly Shmygol",

note = "Funding Information: SW is supported by Action Medical Research and Wellbeing of Women. AS is supported by the BBSRC.",

year = "2007",

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AU - Wray, Susan

AU - Shmygol, Anatoly

N1 - Funding Information: SW is supported by Action Medical Research and Wellbeing of Women. AS is supported by the BBSRC.

PY - 2007/6

Y1 - 2007/6

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AB - This article assesses the nature of the sarcoplasmic reticulum (SR) in uterine smooth muscle. Modern imagining techniques have revealed new information about the location and density of Ca storage and release. Release mechanisms, including IP3 and Ca itself, via ryanodine receptors (RyR), as well as possible roles for cyclic ADP ribose, and the contribution of the SR to relaxation are detailed. The role of the SR Ca-ATPase in both decay of the Ca transient and maintaining Ca homeostasis is reviewed. Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains.

KW - Calcium sparks

KW - Contraction

KW - Myometrium

KW - Sarcoplasmic reticulum

KW - Signalling

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Role of the calcium store in uterine contractility

Abstract

Keywords

ASJC Scopus subject areas

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