Role of the calcium store in uterine contractility

Susan Wray, Anatoly Shmygol

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

This article assesses the nature of the sarcoplasmic reticulum (SR) in uterine smooth muscle. Modern imagining techniques have revealed new information about the location and density of Ca storage and release. Release mechanisms, including IP3 and Ca itself, via ryanodine receptors (RyR), as well as possible roles for cyclic ADP ribose, and the contribution of the SR to relaxation are detailed. The role of the SR Ca-ATPase in both decay of the Ca transient and maintaining Ca homeostasis is reviewed. Recent data on the role of local Ca signals from the SR in contributing to membrane excitability and contractility are discussed, along with interactions with ion channels in lipid microdomains.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume18
Issue number3
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • Calcium sparks
  • Contraction
  • Myometrium
  • Sarcoplasmic reticulum
  • Signalling

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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