Role of the Nervous System in Tumor Angiogenesis

Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali

Research output: Contribution to journalReview articlepeer-review

32 Citations (Scopus)


The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Tumor angiogenesis, growth of new blood vessels, is one of the major prerequisites for tumor growth as tumor cells rely on adequate oxygen and nutrient supply as well as the removal of waste products. Growth factors including VEGF orchestrate the development of angiogenesis. In addition, nervous system via the release of neurotransmitters contributes to tumor angiogenesis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression via regulating tumor angiogenesis. Various neurotransmitters have been reported to play an important role in tumor angiogenesis.

Original languageEnglish
JournalCancer Microenvironment
Issue number1
Publication statusPublished - Jun 1 2018
Externally publishedYes


  • Angiogenesis
  • Cancer
  • Nervous system
  • Neuro-cancer interaction
  • Neuropeptides
  • Neurotransmitters

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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