TY - JOUR
T1 - Role of the Nervous System in Tumor Angiogenesis
AU - Kuol, Nyanbol
AU - Stojanovska, Lily
AU - Apostolopoulos, Vasso
AU - Nurgali, Kulmira
N1 - Funding Information:
Acknowledgements NK was supported by an Australian Postgraduate Research Award, LS and KN was supported by the College of Heath and Biomedicine Victoria University, Australia and VA was supported by the Centre for Chronic Disease, Victoria University, Australia.
Publisher Copyright:
© 2018, Springer Science+Business Media B.V., part of Springer Nature.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Tumor angiogenesis, growth of new blood vessels, is one of the major prerequisites for tumor growth as tumor cells rely on adequate oxygen and nutrient supply as well as the removal of waste products. Growth factors including VEGF orchestrate the development of angiogenesis. In addition, nervous system via the release of neurotransmitters contributes to tumor angiogenesis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression via regulating tumor angiogenesis. Various neurotransmitters have been reported to play an important role in tumor angiogenesis.
AB - The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Tumor angiogenesis, growth of new blood vessels, is one of the major prerequisites for tumor growth as tumor cells rely on adequate oxygen and nutrient supply as well as the removal of waste products. Growth factors including VEGF orchestrate the development of angiogenesis. In addition, nervous system via the release of neurotransmitters contributes to tumor angiogenesis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression via regulating tumor angiogenesis. Various neurotransmitters have been reported to play an important role in tumor angiogenesis.
KW - Angiogenesis
KW - Cancer
KW - Nervous system
KW - Neuro-cancer interaction
KW - Neuropeptides
KW - Neurotransmitters
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U2 - 10.1007/s12307-018-0207-3
DO - 10.1007/s12307-018-0207-3
M3 - Review article
AN - SCOPUS:85045144427
SN - 1875-2292
VL - 11
JO - Cancer Microenvironment
JF - Cancer Microenvironment
IS - 1
ER -