Ruthenium(II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties

Ahmed M. Mansour; Rabaa M. Khaled; Engy Khaled; Salma K. Ahmed; Omneya S. Ismael; Alaa Zeinhom; Hana Magdy; Sara S. Ibrahim; Mennattallah Abdelfatah

doi:10.1016/j.bcp.2022.114991

Ruthenium(II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties

Ahmed M. Mansour, Rabaa M. Khaled, Engy Khaled, Salma K. Ahmed, Omneya S. Ismael, Alaa Zeinhom, Hana Magdy, Sara S. Ibrahim, Mennattallah Abdelfatah

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate immune system, and have anti-inflammatory and antibacterial properties. While the first generation Ru(II) carbonyl prodrugs (CORM-2 and CORM-3) displayed several beneficial biological effects, a search in the literature shows that little work has been done to address the drawbacks of CORM-2/-3, exploring other CO triggered methods for the next generation Ru(CO)₂^II based compounds and examining their valuable biological impact. We present a summary of most work related to Ru(II) carbon monoxide-releasing molecules, protein bioconjugation, and antibacterial and anti-inflammatory properties.

Original language	English
Article number	114991
Journal	Biochemical Pharmacology
Volume	199
DOIs	https://doi.org/10.1016/j.bcp.2022.114991
Publication status	Published - May 2022
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/j.bcp.2022.114991

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title = "Ruthenium(II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties",

abstract = "Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate immune system, and have anti-inflammatory and antibacterial properties. While the first generation Ru(II) carbonyl prodrugs (CORM-2 and CORM-3) displayed several beneficial biological effects, a search in the literature shows that little work has been done to address the drawbacks of CORM-2/-3, exploring other CO triggered methods for the next generation Ru(CO)2II based compounds and examining their valuable biological impact. We present a summary of most work related to Ru(II) carbon monoxide-releasing molecules, protein bioconjugation, and antibacterial and anti-inflammatory properties.",

author = "Mansour, \{Ahmed M.\} and Khaled, \{Rabaa M.\} and Engy Khaled and Ahmed, \{Salma K.\} and Ismael, \{Omneya S.\} and Alaa Zeinhom and Hana Magdy and Ibrahim, \{Sara S.\} and Mennattallah Abdelfatah",

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year = "2022",

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doi = "10.1016/j.bcp.2022.114991",

language = "English",

volume = "199",

journal = "Biochemical Pharmacology",

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T2 - Structural perspective, antimicrobial and anti-inflammatory properties

AU - Mansour, Ahmed M.

AU - Khaled, Rabaa M.

AU - Khaled, Engy

AU - Ahmed, Salma K.

AU - Ismael, Omneya S.

AU - Zeinhom, Alaa

AU - Magdy, Hana

AU - Ibrahim, Sara S.

AU - Abdelfatah, Mennattallah

PY - 2022/5

Y1 - 2022/5

N2 - Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate immune system, and have anti-inflammatory and antibacterial properties. While the first generation Ru(II) carbonyl prodrugs (CORM-2 and CORM-3) displayed several beneficial biological effects, a search in the literature shows that little work has been done to address the drawbacks of CORM-2/-3, exploring other CO triggered methods for the next generation Ru(CO)2II based compounds and examining their valuable biological impact. We present a summary of most work related to Ru(II) carbon monoxide-releasing molecules, protein bioconjugation, and antibacterial and anti-inflammatory properties.

AB - Carbon monoxide has recently emerged to promote tissue regeneration, enhance the innate immune system, and have anti-inflammatory and antibacterial properties. While the first generation Ru(II) carbonyl prodrugs (CORM-2 and CORM-3) displayed several beneficial biological effects, a search in the literature shows that little work has been done to address the drawbacks of CORM-2/-3, exploring other CO triggered methods for the next generation Ru(CO)2II based compounds and examining their valuable biological impact. We present a summary of most work related to Ru(II) carbon monoxide-releasing molecules, protein bioconjugation, and antibacterial and anti-inflammatory properties.

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Ruthenium(II) carbon monoxide releasing molecules: Structural perspective, antimicrobial and anti-inflammatory properties

Abstract

ASJC Scopus subject areas

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