Effects of ryanodine on calcium transients evoked by depolarization of external membrane under voltage clamp conditions or by a train of action potentials under current clamp conditions were studied on isolated dorsal root ganglion neurons of newborn rats. In 70% neurons tested, ryanodine, a blocker of Ca2+-induced Ca2+ release from endoplasmic reticulum, significantly decreased the amplitude of calcium transients. The data obtained indicate that the Ca2+-induced Ca2+ release plays an important role for calcium signal generation in a subpopulation of sensory neurons.
ASJC Scopus subject areas
- General Neuroscience