Ryanodine inhibits calcium transients evoked by action potentials in a subpopulation of rat dorsal root ganglion neurons

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Abstract

Effects of ryanodine on calcium transients evoked by depolarization of external membrane under voltage clamp conditions or by a train of action potentials under current clamp conditions were studied on isolated dorsal root ganglion neurons of newborn rats. In 70% neurons tested, ryanodine, a blocker of Ca2+-induced Ca2+ release from endoplasmic reticulum, significantly decreased the amplitude of calcium transients. The data obtained indicate that the Ca2+-induced Ca2+ release plays an important role for calcium signal generation in a subpopulation of sensory neurons.

Original languageEnglish
Pages (from-to)344-346
Number of pages3
JournalNeurophysiology
Volume26
Issue number6
DOIs
Publication statusPublished - Nov 1994
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology

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