Sample Sizes in Sequential Survival Clinical Trials

N. J.D. Nagelkerke, A. A.M. Hart, J. Strackee

Research output: Contribution to journalArticlepeer-review


In survival clinical trials the response, i.e. (time to) death is delayed. As a result there are at any time patients that have not responded, yet. Given a stopping rule based on the number of deaths, the distribution of the total number of patients that will enter the trial is examined. Besides, a simple approximation to the expected number of patients is presented.

Original languageEnglish
Pages (from-to)709-714
Number of pages6
JournalBiometrical Journal
Issue number7
Publication statusPublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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