SARS-CoV-2 associated pathogenesis, immune dysfunction and involvement of host factors: A comprehensive review

W. Waqar, S. Ismail, Z. Jamil, A. Al-Shehhi, M. Imran, H. F. Hetta, Khalid Muhammad, Yasir Waheed

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Infectious diseases, especially viral infections, have emerged as a major concern for public health in recent years. Recently emerged COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has been declared a pandemic by World Health Organization since March 2020. It was first identified in Wuhan, China, in December 2019 and has since claimed more than a million lives. Complicated symptoms are associated with rising incidence and fatality rates, while many of the vaccine candidates are in the final stages of clinical trials. This review encompasses a summary of existing literature on COVID-19, including the basics of the disease such as the causative agent's genome characterization, modes of transmission of the virus, pathogenesis, and clinical presentations like associated immune responses, neurological manifestations, the variety of host genetic factors influencing the disease and the vulnerability of different groups being affected by COVID-19.

Original languageEnglish
Pages (from-to)7526-7542
Number of pages17
JournalEuropean review for medical and pharmacological sciences
Volume25
Issue number23
DOIs
Publication statusPublished - 2021

Keywords

  • COVID-19
  • Host factors
  • Immune response
  • Pathogenesis
  • SARS-CoV-2 infection

ASJC Scopus subject areas

  • Pharmacology (medical)

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