Screening of gastrointestinal hormone release in patients with lung cancer

Yoshinori Yamashita, Eiji Miyahara, Katsuhiko Shimizu, Tetsuya Toge, Thomas E. Adrian

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The aim of this study was the screening of gastrointestinal (GI) hormones release as possible sensitive tumor markers. The subjects were eight patients with carcinoma of the lung compared with nine healthy controls. Six kinds ofGI hormones were measured by the specific radioimmunoassay. It was evaluated by fasting level (F), increased integrated responses (IIR60, IIR180 pmol/l/min) and total integrated responses (TIR60, TIR180 pmol/l/min) after a meal. The data were analyzed by the Student's t-test. The F of pancreatic polypeptide (PP) was significantly higher in patients than that in healthy controls (24.4 vs. 12.3 pmol/l, p=0.002). Consequently, the sensitivity was 75 % (6 out of 8) and specificity was 100 % (9 out of 9). Almost all parameters of IIR60, IIR180, TIR60 and TIR180 in PP and peptide YY were significantly higher in patients than in healthy controls (p value: 0.00020-0.021). The other four kinds of hormones showed similar results to the healthy controls. These results seem to indicate that PP and PYY would be useful tumor markers for lung cancer in clinical management.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalIn Vivo
Volume17
Issue number2
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Gastrointestinal hormone
  • Lung cancer
  • Pancreatic polypeptide
  • Peptide YY

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Cancer Research
  • Pharmacology

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