Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Hamdy Moselhy; Valsamma Eapen; Nadia A. Akawi; Ali Younis; Badr Salih; Aws R. Othman; Said Yousef; Raymond A. Clarke; Bassam R. Ali

doi:10.1016/j.mgene.2015.07.002

Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Hamdy Moselhy, Valsamma Eapen, Nadia A. Akawi, Ali Younis, Badr Salih, Aws R. Othman, Said Yousef, Raymond A. Clarke, Bassam R. Ali

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Meta Gene
Volume	5
DOIs	https://doi.org/10.1016/j.mgene.2015.07.002
Publication status	Published - Sept 1 2015

Keywords

DISC1
Genetics
NRG3
PDLIM5
PICK1
Schizophrenia

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1016/j.mgene.2015.07.002

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title = "Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients",

abstract = "Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.",

keywords = "DISC1, Genetics, NRG3, PDLIM5, PICK1, Schizophrenia",

author = "Hamdy Moselhy and Valsamma Eapen and Akawi, {Nadia A.} and Ali Younis and Badr Salih and Othman, {Aws R.} and Said Yousef and Clarke, {Raymond A.} and Ali, {Bassam R.}",

note = "Funding Information: We thank the subjects and volunteers for taking part in this study. The project was funded by United Arab Emirates University (grant no. 01-08-8-12/08 ). Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = sep,

day = "1",

doi = "10.1016/j.mgene.2015.07.002",

language = "English",

volume = "5",

pages = "135--139",

journal = "Meta Gene",

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T1 - Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

AU - Moselhy, Hamdy

AU - Eapen, Valsamma

AU - Akawi, Nadia A.

AU - Younis, Ali

AU - Salih, Badr

AU - Othman, Aws R.

AU - Yousef, Said

AU - Clarke, Raymond A.

AU - Ali, Bassam R.

N1 - Funding Information: We thank the subjects and volunteers for taking part in this study. The project was funded by United Arab Emirates University (grant no. 01-08-8-12/08 ). Publisher Copyright: © 2015.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.

AB - Schizophrenia is a clinically and genetically heterogeneous disorder of unknown etiology. PDLIM5 variants have been linked to schizophrenia and other related neuropsychiatric disorders and upregulated in the brain of schizophrenia patients suggesting a possible pathogenic role in disease progression. The aim of this study is to examine the potential association of schizophrenia in Emirati patients with previously reported variants in PDLIM5, PICK1, NRG3 or DISC1 genes. Consequently, we found a secondary association between PDLIM5 variants and the paranoid subtype of schizophrenia in Emirati Arabs suggesting that PDLIM5 may represent a determinate/marker for schizophrenia subtype specification. However, no associations were found with variants in PICK1, NRG3 or DISC1 genes.

KW - DISC1

KW - Genetics

KW - NRG3

KW - PDLIM5

KW - PICK1

KW - Schizophrenia

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DO - 10.1016/j.mgene.2015.07.002

M3 - Article

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SN - 2214-5400

VL - 5

SP - 135

EP - 139

JO - Meta Gene

JF - Meta Gene

ER -

Secondary association of PDLIM5 with paranoid schizophrenia in Emirati patients

Abstract

Keywords

ASJC Scopus subject areas

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