Secretory responses and peptidergic and aminergic innervation of the rat lacrimal gland

E. Adeghate, J. Singh, S. Burrows, F. C. Howarth, T. Donath

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Stimulation of isolated rat lacrimal segments with either vasoactive intestinal polypeptide (VIP). neuropeptide Y (NPY). 5-hydroxytryptamine (5-HT). Dopamine (DOP). Substance P (SP) resulted in marked increases in total protein output. In an attempt to ascertain whether the rat lacrimal gland was innervated with the peptidergic and aminergic nerves containing their respective neurotransmitters, it was necessary to employ conventional immunohistochemical studies. The results demonstrate the presence of numerous intrinsic immunoreactive nerves for VIP. NPY. 5-HT. SP and dopamine-beta- hydroxylase (DBH). The distribution pattern for all these nerves are similar and they are found predominantly on the basal surfaces of the secretory acini and in the interlobular septa of the lacrimal gland. We conclude that the lacrimal gland is innervated by both peptidergic and aminergic nerves which may participate with cholinergic and adrenergic nerves in regulating lacrimal secretion.

Original languageEnglish
Pages (from-to)487-498
Number of pages12
JournalBiogenic Amines
Issue number5
Publication statusPublished - 1994


  • Aminergic
  • Innervation
  • Lacrimal gland
  • Peptidergic
  • Protein secretion
  • Rat

ASJC Scopus subject areas

  • General Neuroscience
  • Pharmacology


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