Stimulation of isolated rat lacrimal segments with either vasoactive intestinal polypeptide (VIP). neuropeptide Y (NPY). 5-hydroxytryptamine (5-HT). Dopamine (DOP). Substance P (SP) resulted in marked increases in total protein output. In an attempt to ascertain whether the rat lacrimal gland was innervated with the peptidergic and aminergic nerves containing their respective neurotransmitters, it was necessary to employ conventional immunohistochemical studies. The results demonstrate the presence of numerous intrinsic immunoreactive nerves for VIP. NPY. 5-HT. SP and dopamine-beta- hydroxylase (DBH). The distribution pattern for all these nerves are similar and they are found predominantly on the basal surfaces of the secretory acini and in the interlobular septa of the lacrimal gland. We conclude that the lacrimal gland is innervated by both peptidergic and aminergic nerves which may participate with cholinergic and adrenergic nerves in regulating lacrimal secretion.
|Number of pages||12|
|Publication status||Published - 1994|
- Lacrimal gland
- Protein secretion
ASJC Scopus subject areas