SEINN: A deep learning algorithm for the stochastic epidemic model

Thomas Torku, Abdul Khaliq, Fathalla Rihan

Research output: Contribution to journalArticlepeer-review


Stochastic modeling predicts various outcomes from stochasticity in the data, parameters and dynamical system. Stochastic models are deemed more appropriate than deterministic models accounting in terms of essential and practical information about a system. The objective of the current investigation is to address the issue above through the development of a novel deep neural network referred to as a stochastic epidemiology-informed neural network. This network learns knowledge about the parameters and dynamics of a stochastic epidemic vaccine model. Our analysis centers on examining the nonlinear incidence rate of the model from the perspective of the combined effects of vaccination and stochasticity. Based on empirical evidence, stochastic models offer a more comprehensive understanding than deterministic models, mainly when we use error metrics. The findings of our study indicate that a decrease in randomness and an increase in vaccination rates are associated with a better prediction of nonlinear incidence rates. Adopting a nonlinear incidence rate enables a more comprehensive representation of the complexities of transmitting diseases. The computational analysis of the proposed method, focusing on sensitivity analysis and overfitting analysis, shows that the proposed method is efficient. Our research aims to guide policymakers on the effects of stochasticity in epidemic models, thereby aiding the development of effective vaccination and mitigation policies. Several case studies have been conducted on nonlinear incidence rates using data from Tennessee, USA.

Original languageEnglish
Pages (from-to)16330-16361
Number of pages32
JournalMathematical Biosciences and Engineering
Issue number9
Publication statusPublished - 2023


  • computational analysis
  • data-driven
  • deep learning
  • nonlinear incidence rate
  • regularization
  • stochastic differential equation
  • stochastic epidemiology informed neural network

ASJC Scopus subject areas

  • Modelling and Simulation
  • General Agricultural and Biological Sciences
  • Computational Mathematics
  • Applied Mathematics


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