Semi-automated dielectrophoretic cell characterisation module for lab-on-chip applications

N. A. Kadri, H. O. Fatoyinbo, M. P. Hughes, F. H. Labeed

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Dielectrophoresis is an electrical phenomenon that occurs when a polarisable particle is placed in non-uniform electrical fields. The magnitude of the generated force is dependent upon the electrophysiological make-up of the particle, therefore the specific DEP profile may be attained for any polarisable particles based on the intrinsic electrical properties alone. Any changes to these parameters may be detected by observing the corresponding DEP spectra. Despite having the advantages of being non-invasive, DEP applications are still not widely used due to the time-consuming processes involved. This study presents the preliminary outcomes in the development of a semi-automated DEP-based cell characterisation tool that allowed concurrent DEP experiments to be conducted serially, thus significantly reducing the time taken to complete the required sets of experiments. The results showed that the system is capable of producing a DEP spectrum for K562 leukaemic cells between the 10 kHz to 1 MHz range in less than 10 minutes, when recorded at eight points per decade.

Original languageEnglish
Title of host publication5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
Pages582-586
Number of pages5
DOIs
Publication statusPublished - 2011
Externally publishedYes
Event5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur, Malaysia
Duration: Jun 20 2011Jun 23 2011

Publication series

NameIFMBE Proceedings
Volume35 IFMBE
ISSN (Print)1680-0737

Conference

Conference5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
Country/TerritoryMalaysia
CityKuala Lumpur
Period6/20/116/23/11

Keywords

  • cancer cells
  • Dielectrophoresis
  • lab-on-chip

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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