TY - GEN
T1 - Semi-empirical Modeling for DNA Bases via Z-shaped Graphene Nanoribbon with a Nanopore
AU - Wasfi, Asma
AU - Awwad, Falah
N1 - Publisher Copyright:
© 2019 IEEE.
PY - 2019/11
Y1 - 2019/11
N2 - DNA base detection is a vastly advancing technology to obtain the bases sequence in human genome thus allowing for recognition and medication of disease. Acquiring reliable, quick, and cheap DNA sequencing facilitates personalized medicine procedure where right medication will be given to patients. In this article, a semi-empirical model is presented for calculating electron transport properties for the z-shaped sensor to identify the DNA sequence. The z-shaped sensor is made of two metallic electrodes of zigzag graphene nanoribbon (ZGNR) connected through a semiconducting channel with a pore in the middle where DNA bases are translocated. The channel is made of armchair graphene nanoribbon (AGNR) which is semiconducting. Semi-empirical model and non-equilibrium Green's function are utilized to ananlyze the various electronic characteristics. The semi-empirical model used is an expansion of the extended Hückel technique with self-consistent Hartree potential. Using the non-equilibrium Green's function combined with self-consistent extended Hückel (NEGF+SC-EH), we show that each of the bases placed within the pore whose edge carbon atoms are passivated with nitrogen leads to a unique current. Several electronic properties are studied such as electrical current and transmission spectrum of DNA bases within the sensor's nanopore. These characteristics are investigated with modification of base orientation. Our study produced unique current for each of the DNA bases inside the pore.
AB - DNA base detection is a vastly advancing technology to obtain the bases sequence in human genome thus allowing for recognition and medication of disease. Acquiring reliable, quick, and cheap DNA sequencing facilitates personalized medicine procedure where right medication will be given to patients. In this article, a semi-empirical model is presented for calculating electron transport properties for the z-shaped sensor to identify the DNA sequence. The z-shaped sensor is made of two metallic electrodes of zigzag graphene nanoribbon (ZGNR) connected through a semiconducting channel with a pore in the middle where DNA bases are translocated. The channel is made of armchair graphene nanoribbon (AGNR) which is semiconducting. Semi-empirical model and non-equilibrium Green's function are utilized to ananlyze the various electronic characteristics. The semi-empirical model used is an expansion of the extended Hückel technique with self-consistent Hartree potential. Using the non-equilibrium Green's function combined with self-consistent extended Hückel (NEGF+SC-EH), we show that each of the bases placed within the pore whose edge carbon atoms are passivated with nitrogen leads to a unique current. Several electronic properties are studied such as electrical current and transmission spectrum of DNA bases within the sensor's nanopore. These characteristics are investigated with modification of base orientation. Our study produced unique current for each of the DNA bases inside the pore.
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U2 - 10.1109/NANOMED49242.2019.9130612
DO - 10.1109/NANOMED49242.2019.9130612
M3 - Conference contribution
AN - SCOPUS:85088297146
T3 - IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
SP - 16
EP - 21
BT - 2019 IEEE 13th International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
PB - IEEE Computer Society
T2 - 13th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
Y2 - 21 November 2019 through 24 November 2019
ER -
