Sequelles neurologiques secondaires a une intoxication aigue au lithium

Translated title of the contribution: Secondary neurological sequelae resulting from acute lithium poisoning

Mario Roy, Emmanuel Stip, Deborah N. Black, Vivianne Lew, Robert Langlois

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Objective: To review the literature on the permanent neurological sequelae resulting from acute lithium poisoning. Method: Sixty-six articles were reviewed in English and in French. They were accessed through Medline and cover the period from 1968 to 1997. Results: Fifty-nine case studies were broken down into 3 groups: lithium intoxications without a neuroleptic that has provoked a cerebellar syndrome; those in which there was a neuroleptic; and those with diverse neurological consequences, with or without a neuroleptic. Conclusions: Lithium has an intrinsic toxicity for the central nervous system and provokes a tropism specific to the cerebellum. The association with neuroleptics appears to increase toxicity as well as some associated factors, including infections and the rapid correction of the lithium level in the blood. We discuss the psychopathological mechanisms invoked to explain lithium's neurotoxicity.

Translated title of the contributionSecondary neurological sequelae resulting from acute lithium poisoning
Original languageFrench
Pages (from-to)671-679
Number of pages9
JournalCanadian Journal of Psychiatry
Issue number7
Publication statusPublished - 1999
Externally publishedYes


  • Antipsychotics
  • Ataxia
  • Cerebellum
  • Lithium
  • Neurological side effects
  • Toxicity

ASJC Scopus subject areas

  • Psychiatry and Mental health


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