Seroprevalence of dengue antibodies, annual incidence and risk factors among children in southern Vietnam

Khoa T.D. Thai, Tran Quang Binh, Phan Trong Giao, Hoang Lan Phuong, Le Quoc Hung, Nguyen Van Nam, Tran Thanh Nga, Jan Groen, Nico Nagelkerke, Peter J. De Vries

Research output: Contribution to journalReview articlepeer-review

95 Citations (Scopus)


Dengue is highly endemic in southern Vietnam and all four serotypes of dengue virus have already been identified. To determine the age-specific prevalence of dengue and associated risk factors, we conducted a serological study at two primary schools and assessed risk factors by analysing children's questionnaires and household surveys. Sera were collected from 961 primary schoolchildren in Binh Thuan Province and tested for the presence of dengue virus serum antibodies using an indirect immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA). The antibody prevalence of the total population was 65.7% (n = 631) which increased from 53.0 to 88.2% with age. The annual incidence of a first dengue infection, estimated by binary regression of the seroprevalence by age, was 11.7%. Interestingly, the prevalence of dengue IgG antibodies was significantly higher in children who confirmed using a pit latrine (RR 1.467, 95% CI: 1.245-1.730) and whose domestic environment contained discarded cans (RR 1.238, 95% CI: 1.042-1.470) and pigs (RR 1.228, 95% CI: 1.002-1.504). The epidemiology ol: dengue in southern Vietnam is stable with a constantly high annual incidence of first infections. Transmission occurs mainly pen-domestically, which has important public health implications.

Original languageEnglish
Pages (from-to)379-386
Number of pages8
JournalTropical Medicine and International Health
Issue number4
Publication statusPublished - Apr 2005
Externally publishedYes


  • Dengue
  • Incidence
  • Regression analysis
  • Risk factors
  • Seroepidemiological studies
  • Vietnam

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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