The Drosophila learning mutant rutabaga is defective in short-term memory and has a reduced intracellular cyclic adenosine monophosphate (cAMP) concentration. The delayed-rectifier potassium current (IKDR) was measured from cultured (2 days) wild-type and rutabaga neurons. IKDR was smaller in rutabaga neurons (382 ± 41 pA) than in wild-type neurons (542 ± 33 pA). IKDR was measured from neurons before and after addition of serotonin to the external solution. IKDR was reduced by serotonin in wildtype (↓37 ± 7%) and rutabaga (↓33 ± 6%) neurons (single-cell studies). In the presence of serotonin, IKDR was smaller in rutabaga (218 ± 24 pA) than in wild-type (426 ± 35 pA) neurons (population studies). These results indicate that serotonin has affected IKDR so that the inherent difference between the two genotypes was preserved.
- Learning mutants
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