Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19

Karuna M. Das; Rajvir Singh; Sandeep Subramanya; Shreesh Kumar Ojha; Taleb Almansoori; Dilip Gokhale; Jamal Aldeen Alkoteesh

doi:10.2217/fvl-2021-0118

Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19

Karuna M. Das, Rajvir Singh, Sandeep Subramanya, Shreesh Kumar Ojha, Taleb Almansoori, Dilip Gokhale, Jamal Aldeen Alkoteesh

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Aim: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. Materials & methods: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. Results: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. Conclusion: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia.

Original language	English
Pages (from-to)	601-609
Number of pages	9
Journal	Future Virology
Volume	16
Issue number	9
DOIs	https://doi.org/10.2217/fvl-2021-0118
Publication status	Published - Sept 2021

Keywords

COVID-19
Chest CT
LDH
serum ferritin

ASJC Scopus subject areas

Virology

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10.2217/fvl-2021-0118

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title = "Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19",

abstract = "Aim: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. Materials & methods: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. Results: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. Conclusion: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia.",

keywords = "COVID-19, Chest CT, LDH, serum ferritin",

author = "Das, {Karuna M.} and Rajvir Singh and Sandeep Subramanya and Ojha, {Shreesh Kumar} and Taleb Almansoori and Dilip Gokhale and Alkoteesh, {Jamal Aldeen}",

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T1 - Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19

AU - Das, Karuna M.

AU - Singh, Rajvir

AU - Subramanya, Sandeep

AU - Ojha, Shreesh Kumar

AU - Almansoori, Taleb

AU - Gokhale, Dilip

AU - Alkoteesh, Jamal Aldeen

PY - 2021/9

Y1 - 2021/9

N2 - Aim: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. Materials & methods: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. Results: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. Conclusion: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia.

AB - Aim: This study aimed to investigate whether serum biochemical parameters can be used as a surrogate for chest computed tomography (CT) in the diagnosis of COVID-19 in pediatric patients. Materials & methods: We evaluated potential associations between various serum biochemical markers and the COVID-reporting and data system (RADS) pneumonia grading system in 53 individuals with confirmed COVID-19. Results: A total of 28 chest CT scans (52.8%) were abnormal. Patients with confirmed COVID-19 on CT showed a statistically significant increase in lactate dehydrogenase (186.4 ± 56.5 vs 228.4 ± 60.6; p = 0.01), which was significantly correlated with the COVID-RADS pneumonia grading system. Conclusion: Lactate dehydrogenase can be used as a surrogate marker for chest CT in children with COVID-19. This can reduce exposure to ionizing radiation during initial diagnostic procedures in children with suspected COVID-19 pneumonia.

KW - COVID-19

KW - Chest CT

KW - LDH

KW - serum ferritin

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Serum biochemical parameters as a surrogate marker for chest computed tomography in children with COVID-19

Abstract

Keywords

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