TY - JOUR
T1 - Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum
AU - Kamal-Eldin, Afaf
AU - Pettersson, Dan
AU - Appelqvist, Lars Åke
PY - 1995/6/1
Y1 - 1995/6/1
N2 - Six groups of rats were fed diets low, but adequate, in α-tocopherol but high in γ-tocopherol. The six diets differed only in their contents (0, 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg, respectively) of sesamin, a lignan from sesame oil. After four weeks of ad libitum feeding, the rats were sacrificed and the concentrations of α- and γ-tocopherols were measured in the plasma, livers, and lungs. Sesamin-feeding increased γ-tocopherol and γ-/α-tocopherol ratios in the plasma (P<0.05), liver (P<0.001), and lungs (P<0.001). The increase was non-significant for α-tocopherol. Thus, sesamin appears to spare γ-tocopherol in rat plasma and tissues, and this effect persists in the presence of α-tocopherol, a known competitor to γ-tocopherol. This suggests that the bioavailability of γ-tocopherol is enhanced in phenol-containing diets as compared with purified diets.
AB - Six groups of rats were fed diets low, but adequate, in α-tocopherol but high in γ-tocopherol. The six diets differed only in their contents (0, 0.25, 0.5, 1.0, 2.0, and 4.0 g/kg, respectively) of sesamin, a lignan from sesame oil. After four weeks of ad libitum feeding, the rats were sacrificed and the concentrations of α- and γ-tocopherols were measured in the plasma, livers, and lungs. Sesamin-feeding increased γ-tocopherol and γ-/α-tocopherol ratios in the plasma (P<0.05), liver (P<0.001), and lungs (P<0.001). The increase was non-significant for α-tocopherol. Thus, sesamin appears to spare γ-tocopherol in rat plasma and tissues, and this effect persists in the presence of α-tocopherol, a known competitor to γ-tocopherol. This suggests that the bioavailability of γ-tocopherol is enhanced in phenol-containing diets as compared with purified diets.
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U2 - 10.1007/BF02537023
DO - 10.1007/BF02537023
M3 - Article
C2 - 7651076
AN - SCOPUS:0029045399
SN - 0024-4201
VL - 30
SP - 499
EP - 505
JO - Lipids
JF - Lipids
IS - 6
ER -