Sesamin modulates gene expression without corresponding effects on fatty acids in Atlantic salmon (Salmo salar L.)

A. Schiller Vestergren, L. Wagner, J. Pickova, G. Rosenlund, A. Kamal-Eldin, S. Trattner

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


This study examined the effects of sesamin inclusion in vegetable oil-based diets fed to Atlantic salmon (Salmo salar L.). The diets used differed in n-6/n-3 fatty acid (FA) ratio (0.5 and 1) and sesamin content (high 5.8 g/kg, low 1.16 g/kg and no sesamin). The oils used in the feeds were a mixture of rapeseed, linseed and palm oil. Fish were fed for 4 months. Fatty acids and expression of hepatic genes involved in transcription, lipid uptake, desaturation, elongation and β-oxidation were measured. No major effects on the percentage of DHA in white muscle, liver triacylglycerol and phospholipid fraction were detected. Genes involved in β-oxidation, elongation and desaturation were affected by sesamin addition. Limited effects were seen on any of the transcription factors tested and no effect was seen on the expression of peroxisome proliferator-activated receptors (PPAR). Expression of both SREBP-1 and SREBP-2 increased with sesamin addition. It was concluded that supplementation of fish feed with a high level of sesamin had a negative effect on the growth rate and live weight and did not alter the proportions of DHA in tissues even though gene expression was affected. Thus, more studies are needed to formulate a diet that would increase the percentage of DHA in fish without negative effects on fish growth.

Original languageEnglish
Pages (from-to)897-911
Number of pages15
Issue number9
Publication statusPublished - Sept 2012
Externally publishedYes


  • DHA
  • Desaturation
  • Elongation
  • N-6/n-3 Fatty acid ratio
  • PGC-1a
  • Vegetable oil
  • β-Oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology


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