TY - JOUR
T1 - Sex differences in memory processing in schizophrenia
T2 - An event-related potential (ERP) study
AU - Guillem, François
AU - Mendrek, Adrianna
AU - Lavoie, Marc E.
AU - Pampoulova, Tania
AU - Stip, Emmanuel
N1 - Funding Information:
This research was supported by the Canadian Institutes for Health Research (CIHR-MOP-49530).
Funding Information:
François Guillem and Adrianna Mendrek are supported by the Fond de la Recherche en Santé du Québec. We are particularly grateful to all the nursing personnel of the L-H Lafontaine Hospital and affiliated outpatient clinics for their helpful assistance in patient's approach and recruitment.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Recently, research has begun to examine sex differences in cognitive functions in schizophrenia and whether such sex differences reflect normal, exaggerated, or reversed sexual dimorphism. This study examined this question by using event-related potentials (ERPs). ERPs were recorded in a recognition memory task in 18 patients and 18 matched control subjects. On an early frontal component, the results show an interaction between sex and pathological condition that results in an apparent reversed sexual dimorphism. On mid-latency components, patients show no sex difference on a frontal component, but a difference on the posterior component, whereas healthy subjects show a reverse pattern. Finally, late components show sex difference in the same direction as healthy subjects. These results indicate that the influence of sex on the cognitive impairment in schizophrenia is not homogenous across the information-processing cascade.
AB - Recently, research has begun to examine sex differences in cognitive functions in schizophrenia and whether such sex differences reflect normal, exaggerated, or reversed sexual dimorphism. This study examined this question by using event-related potentials (ERPs). ERPs were recorded in a recognition memory task in 18 patients and 18 matched control subjects. On an early frontal component, the results show an interaction between sex and pathological condition that results in an apparent reversed sexual dimorphism. On mid-latency components, patients show no sex difference on a frontal component, but a difference on the posterior component, whereas healthy subjects show a reverse pattern. Finally, late components show sex difference in the same direction as healthy subjects. These results indicate that the influence of sex on the cognitive impairment in schizophrenia is not homogenous across the information-processing cascade.
KW - Event-related potentials
KW - Memory
KW - Schizophrenia
KW - Sex
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U2 - 10.1016/j.pnpbp.2008.08.002
DO - 10.1016/j.pnpbp.2008.08.002
M3 - Article
C2 - 18727949
AN - SCOPUS:58149502658
SN - 0278-5846
VL - 33
SP - 1
EP - 10
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 1
ER -