Abstract
We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. It was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus. Moreover, SIV RNA was packaged and propagated by core particles of the heterologous lentivirus, HIV-1. These results indicate that coinfection of cells with SIV and other retroviruses could lead to infection of new cell types in nature.
| Original language | English |
|---|---|
| Pages (from-to) | 69-73 |
| Number of pages | 5 |
| Journal | Journal of medical primatology |
| Volume | 21 |
| Issue number | 2-3 |
| Publication status | Published - 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)