Simian immunodeficiency virus vectors: replication and pseudotyping.

T. A. Rizvi, A. T. Panganiban

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. It was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus. Moreover, SIV RNA was packaged and propagated by core particles of the heterologous lentivirus, HIV-1. These results indicate that coinfection of cells with SIV and other retroviruses could lead to infection of new cell types in nature.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalJournal of medical primatology
Issue number2-3
Publication statusPublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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