Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families

June E. Swinburne; Mike Boursnell; Gemma Hill; Louise Pettitt; Twink Allen; Bhanu Chowdhary; Telhisa Hasegawa; Masahiko Kurosawa; Tosso Leeb; Suguru Mashima; James R. Mickelson; Terje Raudsepp; Teruaki Tozaki; Matthew Binns

doi:10.1016/j.ygeno.2005.09.001

Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families

June E. Swinburne, Mike Boursnell, Gemma Hill, Louise Pettitt, Twink Allen, Bhanu Chowdhary, Telhisa Hasegawa, Masahiko Kurosawa, Tosso Leeb, Suguru Mashima, James R. Mickelson, Terje Raudsepp, Teruaki Tozaki, Matthew Binns

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.

Original language	English
Pages (from-to)	1-29
Number of pages	29
Journal	Genomics
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/j.ygeno.2005.09.001
Publication status	Published - Jan 2006
Externally published	Yes

Keywords

Comparative map
Genetic map
Horse
Linkage map
Radiation hybrid map

ASJC Scopus subject areas

Genetics

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10.1016/j.ygeno.2005.09.001

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Swinburne, J. E., Boursnell, M., Hill, G., Pettitt, L., Allen, T., Chowdhary, B., Hasegawa, T., Kurosawa, M., Leeb, T., Mashima, S., Mickelson, J. R., Raudsepp, T., Tozaki, T., & Binns, M. (2006). Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. Genomics, 87(1), 1-29. https://doi.org/10.1016/j.ygeno.2005.09.001

Swinburne, JE, Boursnell, M, Hill, G, Pettitt, L, Allen, T, Chowdhary, B, Hasegawa, T, Kurosawa, M, Leeb, T, Mashima, S, Mickelson, JR, Raudsepp, T, Tozaki, T & Binns, M 2006, 'Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families', Genomics, vol. 87, no. 1, pp. 1-29. https://doi.org/10.1016/j.ygeno.2005.09.001

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title = "Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families",

abstract = "A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.",

keywords = "Comparative map, Genetic map, Horse, Linkage map, Radiation hybrid map",

author = "Swinburne, {June E.} and Mike Boursnell and Gemma Hill and Louise Pettitt and Twink Allen and Bhanu Chowdhary and Telhisa Hasegawa and Masahiko Kurosawa and Tosso Leeb and Suguru Mashima and Mickelson, {James R.} and Terje Raudsepp and Teruaki Tozaki and Matthew Binns",

note = "Funding Information: We thank the Horserace Betting Levy Board and the Childwick Trust for generous financial support. We also acknowledge the Dorothy Russell Havemeyer Foundation for their continuing support of collaboration in this field by financing International Workshops. We are grateful to the laboratories that contributed to this effort by providing primers for microsatellite markers, including INRA Centre de Recherches de Jouy, France; the College of Veterinary Medicine, University of Minnesota; the Equine Research Institute, Japan Racing Association, Japan; Uppsala University, Sweden; and the Norwegian College of Veterinary Medicine, Oslo, Norway. ",

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AU - Pettitt, Louise

AU - Allen, Twink

AU - Chowdhary, Bhanu

AU - Hasegawa, Telhisa

AU - Kurosawa, Masahiko

AU - Leeb, Tosso

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AU - Mickelson, James R.

AU - Raudsepp, Terje

AU - Tozaki, Teruaki

AU - Binns, Matthew

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N2 - A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.

AB - A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.

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KW - Horse

KW - Linkage map

KW - Radiation hybrid map

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Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families

Abstract

Keywords

ASJC Scopus subject areas

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