Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands

M. Oddsdottir, G. H. Ballantyne, T. E. Adrian, M. J. Zdon, K. A. Zucker, I. M. Modlin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-11M to 10-6M) on half-maximal doses of histamine (10-6 M), pentagastrin (10-6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10-10M to 10-6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W6M) IF release by 69.9 ± 7.2% and the combination of histamine (10-6 M) and pentagastrin (10-6 M) by 64.2 ± 9.,1% This is the first in vitro demonstration that somatostatin inhibits IF release.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalScandinavian Journal of Gastroenterology
Issue number2
Publication statusPublished - 1987
Externally publishedYes


  • Gastric glands
  • Guinea pig
  • Histamine
  • Intrinsic factor
  • Parietal cell
  • Pentagastrin
  • Somatostatin
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands'. Together they form a unique fingerprint.

Cite this