Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands

M. Oddsdottir; G. H. Ballantyne; T. E. Adrian; M. J. Zdon; K. A. Zucker; I. M. Modlin

doi:10.3109/00365528708991885

Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands

M. Oddsdottir, G. H. Ballantyne, T. E. Adrian, M. J. Zdon, K. A. Zucker, I. M. Modlin

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-¹¹M to 10^-6M) on half-maximal doses of histamine (10^-6 M), pentagastrin (10^-6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10^-10M to 10^-6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W⁶M) IF release by 69.9 ± 7.2% and the combination of histamine (10^-6 M) and pentagastrin (10^-6 M) by 64.2 ± 9.,1% This is the first in vitro demonstration that somatostatin inhibits IF release.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Scandinavian Journal of Gastroenterology
Volume	22
Issue number	2
DOIs	https://doi.org/10.3109/00365528708991885
Publication status	Published - 1987
Externally published	Yes

Keywords

Gastric glands
Guinea pig
Histamine
Intrinsic factor
Parietal cell
Pentagastrin
Somatostatin
Stomach

ASJC Scopus subject areas

Gastroenterology

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10.3109/00365528708991885

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title = "Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands",

abstract = "The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-11M to 10-6M) on half-maximal doses of histamine (10-6 M), pentagastrin (10-6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10-10M to 10-6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W6M) IF release by 69.9 ± 7.2% and the combination of histamine (10-6 M) and pentagastrin (10-6 M) by 64.2 ± 9.,1% This is the first in vitro demonstration that somatostatin inhibits IF release.",

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author = "M. Oddsdottir and Ballantyne, {G. H.} and Adrian, {T. E.} and Zdon, {M. J.} and Zucker, {K. A.} and Modlin, {I. M.}",

year = "1987",

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language = "English",

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AU - Oddsdottir, M.

AU - Ballantyne, G. H.

AU - Adrian, T. E.

AU - Zdon, M. J.

AU - Zucker, K. A.

AU - Modlin, I. M.

PY - 1987

Y1 - 1987

N2 - The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-11M to 10-6M) on half-maximal doses of histamine (10-6 M), pentagastrin (10-6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10-10M to 10-6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W6M) IF release by 69.9 ± 7.2% and the combination of histamine (10-6 M) and pentagastrin (10-6 M) by 64.2 ± 9.,1% This is the first in vitro demonstration that somatostatin inhibits IF release.

AB - The aim of our study was to examine the direct effect of somatostatin on histamine-and pentagastrin-stimulated intrinsic factor (IF) release in collagenase-dispersed guinea pig gastric glands. The effect of somatostatin (10-11M to 10-6M) on half-maximal doses of histamine (10-6 M), pentagastrin (10-6 M), and both histamine and pentagastrin together was tested. All tested concentrations of histamine significantly stimulated IF release. Pentagastrin (10-10M to 10-6 M) inconsistently stimulated IF release. The quantity of IF release stimulated by histamine and pentagastrin together was approximately the additive sum of that produced by either agent alone. Somatostatin M) inhibited histamine-stimulated (W6M) IF release by 69.9 ± 7.2% and the combination of histamine (10-6 M) and pentagastrin (10-6 M) by 64.2 ± 9.,1% This is the first in vitro demonstration that somatostatin inhibits IF release.

KW - Gastric glands

KW - Guinea pig

KW - Histamine

KW - Intrinsic factor

KW - Parietal cell

KW - Pentagastrin

KW - Somatostatin

KW - Stomach

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Somatostatin inhibition of intrinsic factor secretion from isolated Guinea pig gastric glands

Abstract

Keywords

ASJC Scopus subject areas

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