Space-time cluster analysis of invasive meningococcal disease

Christian J.P.A. Hoebe, Hester De Melker, Lodewijk Spanjaard, Jacob Dankert, Nico Nagelkerke

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Clusters are recognized when meningococcal cases of the same phenotypic strain (markers: serogroup, serotype, and subtype) occur in spatial and temporal proximity. The incidence of such clusters was compared to the incidence that would be expected by chance by using space-time nearest-neighbor analysis of 4,887 confirmed invasive meningococcal cases identified in the 9-year surveillance period 1993-2001 in the Netherlands. Clustering beyond chance only occurred among the closest neighboring cases (comparable to secondary cases) and was small (3.1%, 95% confidence interval 2.1%-4.1%).

Original languageEnglish
Pages (from-to)1621-1626
Number of pages6
JournalEmerging Infectious Diseases
Issue number9
Publication statusPublished - Sept 2004
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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