Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila

B. Starling Emerald, Stephen M. Cohen

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Antennapedia is one of the homeotic selector genes required for specification of segment identity in Drosophila. Dominant mutations that ectopically express Antennapedia cause transformation of antenna to leg. Loss-of-function mutations cause partial transformation of leg to antenna. Here we examine the role of Antennapedia in the establishment of leg identity in light of recent advances in our understanding of antennal development. In Antennapedia mutant clones in the leg disc, Homothorax and Distal-less are coexpressed and act via spineless to transform proximal femur to antenna. Antennapedia is negatively regulated during leg development by Distal-less, spineless, and dachshund and this reduced Antennapedia expression is needed for the proper development of distal leg elements. These findings suggest that the temporal and spatial regulation of the homeotic selector gene Antennapedia in the leg disc is necessary for normal leg development in Drosophila.

Original languageEnglish
Pages (from-to)462-472
Number of pages11
JournalDevelopmental Biology
Volume267
Issue number2
DOIs
Publication statusPublished - Mar 15 2004
Externally publishedYes

Keywords

  • Antp
  • Dll
  • Drosophila
  • Leg development
  • dac
  • hth
  • ss

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Spatial and temporal regulation of the homeotic selector gene Antennapedia is required for the establishment of leg identity in Drosophila'. Together they form a unique fingerprint.

Cite this