sRNAs and the virulence of Salmonella enterica serovar Typhimurium

Magali Hébrard, Carsten Kröger, Shabarinath Srikumar, Aoife Colgan, Kristian Händler, Jay C.D. Hinton

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the posttranscriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.

Original languageEnglish
Pages (from-to)437-445
Number of pages9
JournalRNA Biology
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • Post-transcriptional regulation
  • Salmonella typhimurium
  • Virulence
  • sRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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