sRNAs and the virulence of Salmonella enterica serovar Typhimurium

Magali Hébrard; Carsten Kröger; Shabarinath Srikumar; Aoife Colgan; Kristian Händler; Jay C.D. Hinton

doi:10.4161/rna.20480

sRNAs and the virulence of Salmonella enterica serovar Typhimurium

Magali Hébrard, Carsten Kröger, Shabarinath Srikumar, Aoife Colgan, Kristian Händler, Jay C.D. Hinton

Research output: Contribution to journal › Review article › peer-review

54 Citations (Scopus)

Abstract

The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the posttranscriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.

Original language	English
Pages (from-to)	437-445
Number of pages	9
Journal	RNA Biology
Volume	9
Issue number	4
DOIs	https://doi.org/10.4161/rna.20480
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

Post-transcriptional regulation
Salmonella typhimurium
Virulence
sRNA

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/rna.20480

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title = "sRNAs and the virulence of Salmonella enterica serovar Typhimurium",

abstract = "The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the posttranscriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.",

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author = "Magali H{\'e}brard and Carsten Kr{\"o}ger and Shabarinath Srikumar and Aoife Colgan and Kristian H{\"a}ndler and Hinton, {Jay C.D.}",

note = "Funding Information: In future, technical advances promise to extend the applicability We are grateful to anonymous reviewers for their insightful of RNA-seq for the monitoring of transcriptional changes in comments, to Karsten Hokamp for assistance with Figure 2 and complex environments or from the very low (femtomolar) amounts to Science Foundation Ireland for financial support under Grant of RNA obtained from infected animals.89,90 Another challenge Number 08/IN.1/B2104. will be to simplify the identification of mRNA targets. Until now,",

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AU - Hébrard, Magali

AU - Kröger, Carsten

AU - Srikumar, Shabarinath

AU - Colgan, Aoife

AU - Händler, Kristian

AU - Hinton, Jay C.D.

N1 - Funding Information: In future, technical advances promise to extend the applicability We are grateful to anonymous reviewers for their insightful of RNA-seq for the monitoring of transcriptional changes in comments, to Karsten Hokamp for assistance with Figure 2 and complex environments or from the very low (femtomolar) amounts to Science Foundation Ireland for financial support under Grant of RNA obtained from infected animals.89,90 Another challenge Number 08/IN.1/B2104. will be to simplify the identification of mRNA targets. Until now,

PY - 2012/4

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N2 - The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the posttranscriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.

AB - The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the posttranscriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.

KW - Post-transcriptional regulation

KW - Salmonella typhimurium

KW - Virulence

KW - sRNA

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sRNAs and the virulence of Salmonella enterica serovar Typhimurium

Abstract

Keywords

ASJC Scopus subject areas

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