Abstract
Objective: The purpose of the study was to compare concentrations of inflammatory and Th1/Th2 cytokines in serum obtained from women with preeclampsia or severe pregnancy hypertension versus normotensive controls. Material and methods: The study group consisted of 34 pregnant women with hypertension over 140/90mmHg and proteinuria over 0,3 g/day or severe pregnancy hypertension. 16 healthy pregnant women comprised the control group. The concentration of IL-2, IL-4, IL-6, IL-10, TNFα and IFNγ was measured with Cytometric Bead Array Human Th1/Th2 Cytokine Kit II (Becton Dickinson). U-Mann Whitney test was used for the comparison of the results. Results: We found statistically significantly increased concentrations of IFNγ: 8.4±5.3pg/ml vs. 4.2±3.2pg/ml (p=0.02), TNFα: 1.5±0,7pg/ml vs. 0.7±0.3pg/ml (p=0,04) and IL-2: 1.3±0.6pg/ml vs. 0.6±0.4pg/ml (p=0.01) in the studied group. The level of IL-6 35.5±21.0pg/ml vs. 19.8±12.3pg/ml was also increased but the difference did not reach statistical significance. Concentrations of IL-4 and IL-10 were similar in both groups. Conclusion: Increased concentrations of Th1 cytokines (IFNγ, IL-2) in the serum of women with preeclampsia suggests an exaggerated cytotoxic activity of blood in this pathology, accompanied by an increase in the levels of inflammatory cytokines TNFα and IL-6.
| Translated title of the contribution | Levels of immunoreactive cytokines in serum of women with preeclampsia or severe pregnancy hypertension |
|---|---|
| Original language | Polish |
| Pages (from-to) | 192-196 |
| Number of pages | 5 |
| Journal | Ginekologia Polska |
| Volume | 81 |
| Issue number | 3 |
| Publication status | Published - Mar 2010 |
| Externally published | Yes |
Keywords
- Cytokines
- Immunology
- Preeclampsia
- Pregnancy
ASJC Scopus subject areas
- Obstetrics and Gynaecology
