TY - JOUR
T1 - Staging of head and neck cancer
AU - Ennis, Ronald D.
AU - Knisely, Jonathan P.s.
AU - Wilson, Lynn D.
AU - Pantel, Klaus
AU - Gath, Hans
AU - Heissler, Ernst
AU - Kao, Gary D.
AU - Rudoltz, Marc
AU - Denic, Srdjan
AU - Brennan, Joseph A.
AU - Mao, li
AU - Sidransky, David
PY - 1995/6/29
Y1 - 1995/6/29
N2 - To the Editor: Brennan et al. (Feb. 16 issue)1 are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.2 The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.
AB - To the Editor: Brennan et al. (Feb. 16 issue)1 are to be commended for their important and well-executed study. This is an excellent example of the use of emerging molecular-biology techniques to address important clinical questions. The clinical usefulness of the study would have been augmented, however, if the authors had provided details of the radiotherapy administered. Because radiation kills cells exponentially, its success is inversely related to the log of the clonogenic cells within the treated volume.2 The tumor-cell burden is higher in patients with positive margins, and it is for this reason that radiation decreases the rate of.
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U2 - 10.1056/NEJM199506293322613
DO - 10.1056/NEJM199506293322613
M3 - Letter
C2 - 7619166
AN - SCOPUS:0029653997
SN - 0028-4793
VL - 332
SP - 1787
EP - 1790
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -