Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Maria Serra-Blasco; Joaquim Radua; Carles Soriano-Mas; Alba Gómez-Benlloch; Daniel Porta-Casteràs; Marta Carulla-Roig; Anton Albajes-Eizagirre; Danilo Arnone; Paul Klauser; Eric J. Canales-Rodríguez; Kevin Hilbert; Toby Wise; Yuqui Cheng; Sevdalina Kandilarova; David Mataix-Cols; Eduard Vieta; Esther Via; Narcís Cardoner

doi:10.1016/j.neubiorev.2021.07.002

Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Maria Serra-Blasco, Joaquim Radua, Carles Soriano-Mas, Alba Gómez-Benlloch, Daniel Porta-Casteràs, Marta Carulla-Roig, Anton Albajes-Eizagirre, Danilo Arnone, Paul Klauser, Eric J. Canales-Rodríguez, Kevin Hilbert, Toby Wise, Yuqui Cheng, Sevdalina Kandilarova, David Mataix-Cols, Eduard Vieta, Esther Via, Narcís Cardoner

Department of Psychiatry

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Original language	English
Pages (from-to)	269-281
Number of pages	13
Journal	Neuroscience and Biobehavioral Reviews
Volume	129
DOIs	https://doi.org/10.1016/j.neubiorev.2021.07.002
Publication status	Published - Oct 2021

Keywords

Anxiety disorders
Comorbidities
Gray matter volume
Major depressive disorder
Meta-analysis
Neuropsychiatry
Posttraumatic stress disorder
Structural neuroimaging

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

Access to Document

10.1016/j.neubiorev.2021.07.002

Cite this

Serra-Blasco, M., Radua, J., Soriano-Mas, C., Gómez-Benlloch, A., Porta-Casteràs, D., Carulla-Roig, M., Albajes-Eizagirre, A., Arnone, D., Klauser, P., Canales-Rodríguez, E. J., Hilbert, K., Wise, T., Cheng, Y., Kandilarova, S., Mataix-Cols, D., Vieta, E., Via, E., & Cardoner, N. (2021). Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis. Neuroscience and Biobehavioral Reviews, 129, 269-281. https://doi.org/10.1016/j.neubiorev.2021.07.002

Serra-Blasco, M, Radua, J, Soriano-Mas, C, Gómez-Benlloch, A, Porta-Casteràs, D, Carulla-Roig, M, Albajes-Eizagirre, A, Arnone, D, Klauser, P, Canales-Rodríguez, EJ, Hilbert, K, Wise, T, Cheng, Y, Kandilarova, S, Mataix-Cols, D, Vieta, E, Via, E & Cardoner, N 2021, 'Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis', Neuroscience and Biobehavioral Reviews, vol. 129, pp. 269-281. https://doi.org/10.1016/j.neubiorev.2021.07.002

@article{38888e9c7aeb452689a733ee99ce4034,

title = "Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis",

abstract = "The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.",

keywords = "Anxiety disorders, Comorbidities, Gray matter volume, Major depressive disorder, Meta-analysis, Neuropsychiatry, Posttraumatic stress disorder, Structural neuroimaging",

author = "Maria Serra-Blasco and Joaquim Radua and Carles Soriano-Mas and Alba G{\'o}mez-Benlloch and Daniel Porta-Caster{\`a}s and Marta Carulla-Roig and Anton Albajes-Eizagirre and Danilo Arnone and Paul Klauser and Canales-Rodr{\'i}guez, {Eric J.} and Kevin Hilbert and Toby Wise and Yuqui Cheng and Sevdalina Kandilarova and David Mataix-Cols and Eduard Vieta and Esther Via and Narc{\'i}s Cardoner",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = oct,

doi = "10.1016/j.neubiorev.2021.07.002",

language = "English",

volume = "129",

pages = "269--281",

journal = "Neuroscience and Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder

T2 - A voxel-based morphometry meta-analysis

AU - Serra-Blasco, Maria

AU - Radua, Joaquim

AU - Soriano-Mas, Carles

AU - Gómez-Benlloch, Alba

AU - Porta-Casteràs, Daniel

AU - Carulla-Roig, Marta

AU - Albajes-Eizagirre, Anton

AU - Arnone, Danilo

AU - Klauser, Paul

AU - Canales-Rodríguez, Eric J.

AU - Hilbert, Kevin

AU - Wise, Toby

AU - Cheng, Yuqui

AU - Kandilarova, Sevdalina

AU - Mataix-Cols, David

AU - Vieta, Eduard

AU - Via, Esther

AU - Cardoner, Narcís

PY - 2021/10

Y1 - 2021/10

N2 - The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

AB - The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

KW - Anxiety disorders

KW - Comorbidities

KW - Gray matter volume

KW - Major depressive disorder

KW - Meta-analysis

KW - Neuropsychiatry

KW - Posttraumatic stress disorder

KW - Structural neuroimaging

UR - http://www.scopus.com/inward/record.url?scp=85112012868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85112012868&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2021.07.002

DO - 10.1016/j.neubiorev.2021.07.002

M3 - Review article

C2 - 34256069

AN - SCOPUS:85112012868

SN - 0149-7634

VL - 129

SP - 269

EP - 281

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this