Structural neuroimaging findings in bipolar disorders

Danilo Arnone, Fadwa Al Mugaddam, Karim Abdel Aziz

Research output: Chapter in Book/Report/Conference proceedingChapter


Neuropsychiatric disorders, including bipolar disorders, affect approximately 2.6% of the world’s population [1] greatly impinging on quality of life as measured by disability adjusted life years (DALYs) [2]. Bipolar disorder is a biologically complex heterogeneous condition. Recent integrated multimodal neuroimaging approaches have expanded our understanding of the pathophysiology and contributed to new advances in developing models for the disorder aiming at identifying brain systems to model mood dysregulation and offer new targets for novel therapeutics. In this chapter, we provide an overview of circuits of mood regulation according to animal and lesion studies, postmortem studies as background to summary information of the most consistent evidence supporting neuroanatomical changes in bipolar disorder by using structural neuroimaging techniques.

Original languageEnglish
Title of host publicationNeurobiology of Bipolar Disorder
Subtitle of host publicationRoad to Novel Therapeutics
Number of pages9
ISBN (Electronic)9780128191828
Publication statusPublished - Jan 1 2020


  • Structural neuroimaging findings in bipolar disorders

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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