Studies on the Rate of Selective Uptake of Amino Acids by Trichinella Larvae in Vivo

T. Alkarmi, M. K. Ijaz, F. K. Dar, S. Galadari, S. Alharbi, M. Alnaaib, S. Abdo

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Groups of C57BL/6J mice, orally infected with 300 larvae each of Trichinella spiralis or T. pseudospiralis were injected with [3H]-alanine, tyrosine, tryptophan or glycine. The incorporation of isotope labelled amino acids into larval proteins was measured at 2, 6, and 12 months post-infection. It was shown that there is a significant increase in the in vivo uptake of isotope labelled amino acids with time by the larvae of T. spiralis and T. pseudospiralis. The level of uptake was highest for tyrosine followed by tryptophan, alanine and then glycine, for both species. The in vivo uptake of amino acids by T. pseudospiralis larvae was always higher than T. spiralis or the host at 6 and 12 months post-infection. At 2 months post-infection, T. spiralis uptake of these amino acids was higher, except for tyrosine. This may be related to the special needs of these larvae during the process of encystation. The higher metabolic requirements of T. pseudospiralis may be related to the higher energy needs of these non encapsulated, highly motile and mobile muscle larvae.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalJournal of Helminthology
Issue number4
Publication statusPublished - Dec 1994

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology


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