Stuve-Wiedemann syndrome: A skeletal dysplasia characterized by bowed long bones

M. A. Begam, W. Alsafi, G. N. Bekdache, F. Chedid, L. Al-Gazali, H. M. Mirghani

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Objective To describe the prenatal sonographic features of Stuve-Wiedemann syndrome (SWS). Methods: A retrospective review of all cases of confirmed SWS during an 8-year period was conducted. Clinical and historical data and outcome of the pregnancies were noted. Fetal biometry, skeletal survey, amniotic fluid volume and associated anomalies were recorded. A sonographic algorithm was proposed to distinguish SWS from other bent bone disorders. Results: In total, there were 10 cases, six of which were diagnosed prenatally. The main prenatal features of SWS were mild-to-moderate micromelia and bowing of the lower limb bones, affecting the tibia more than the femur. There was relative sparing of fibula and upper limb bones, with normal scapulae and clavicles. Camptodactyly was the main associated anomaly. All fetuses developed growth restriction in the late second trimester with oligohydramnios in half of the cases. These features could appear late in pregnancy. Although the thoracic dimensions were normal in the majority of fetuses, respiratory insufficiency, as a result of myotonia, was a leading cause for mortality. Conclusion:s It is possible to diagnose SWS prenatally. SWS is associated with high mortality during the first year of life, and those who survive have high morbidity.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Issue number5
Publication statusPublished - Nov 2011


  • Outcome
  • Prenatal diagnosis
  • Stuve-Wiedemann syndrome

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology


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