TY - JOUR
T1 - Subchronic treatment of rats with nicotine
T2 - Interconversion of nicotinic receptor subtypes in brain
AU - Romanelli, Luciana
AU - Öhman, Birgitta
AU - Adem, Abdu
AU - Nordberg, Agneta
N1 - Funding Information:
This study was supportebdy grants from the Swedish Medical ResearchC ouncil (ProJectN o. 5817)a nd the Swedish TobaccoR esearchC ouncil.The SwedishI nstituteI S gratefully acknowledgedfo r grantmgL uciana Romanelli a mne-month
PY - 1988/3/29
Y1 - 1988/3/29
N2 - A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.
AB - A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.
KW - (Subchronic treatment, Dependence, Rat)
KW - Brain
KW - Nicotinic receptor subtypes
KW - [H]Nicotine
UR - http://www.scopus.com/inward/record.url?scp=0023853527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023853527&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(88)90577-8
DO - 10.1016/0014-2999(88)90577-8
M3 - Article
C2 - 3378577
AN - SCOPUS:0023853527
SN - 0014-2999
VL - 148
SP - 289
EP - 291
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -