Subchronic treatment of rats with nicotine: Interconversion of nicotinic receptor subtypes in brain

Luciana Romanelli; Birgitta Öhman; Abdu Adem; Agneta Nordberg

doi:10.1016/0014-2999(88)90577-8

Subchronic treatment of rats with nicotine: Interconversion of nicotinic receptor subtypes in brain

Luciana Romanelli, Birgitta Öhman, Abdu Adem, Agneta Nordberg

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A significant increase in the number of cortical high-affinity (-)-[³H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[³H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.

Original language	English
Pages (from-to)	289-291
Number of pages	3
Journal	European Journal of Pharmacology
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(88)90577-8
Publication status	Published - Mar 29 1988
Externally published	Yes

Keywords

(Subchronic treatment, Dependence, Rat)
Brain
Nicotinic receptor subtypes
[H]Nicotine

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(88)90577-8

Cite this

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title = "Subchronic treatment of rats with nicotine: Interconversion of nicotinic receptor subtypes in brain",

abstract = "A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.",

keywords = "(Subchronic treatment, Dependence, Rat), Brain, Nicotinic receptor subtypes, [H]Nicotine",

author = "Luciana Romanelli and Birgitta {\"O}hman and Abdu Adem and Agneta Nordberg",

note = "Funding Information: This study was supportebdy grants from the Swedish Medical ResearchC ouncil (ProJectN o. 5817)a nd the Swedish TobaccoR esearchC ouncil.The SwedishI nstituteI S gratefully acknowledgedfo r grantmgL uciana Romanelli a mne-month",

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T1 - Subchronic treatment of rats with nicotine

T2 - Interconversion of nicotinic receptor subtypes in brain

AU - Romanelli, Luciana

AU - Öhman, Birgitta

AU - Adem, Abdu

AU - Nordberg, Agneta

N1 - Funding Information: This study was supportebdy grants from the Swedish Medical ResearchC ouncil (ProJectN o. 5817)a nd the Swedish TobaccoR esearchC ouncil.The SwedishI nstituteI S gratefully acknowledgedfo r grantmgL uciana Romanelli a mne-month

PY - 1988/3/29

Y1 - 1988/3/29

N2 - A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.

AB - A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.

KW - (Subchronic treatment, Dependence, Rat)

KW - Brain

KW - Nicotinic receptor subtypes

KW - [H]Nicotine

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JO - European Journal of Pharmacology

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Subchronic treatment of rats with nicotine: Interconversion of nicotinic receptor subtypes in brain

Abstract

Keywords

ASJC Scopus subject areas

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