Abstract
A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.
Original language | English |
---|---|
Pages (from-to) | 289-291 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 148 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 29 1988 |
Externally published | Yes |
Keywords
- (Subchronic treatment, Dependence, Rat)
- Brain
- Nicotinic receptor subtypes
- [H]Nicotine
ASJC Scopus subject areas
- Pharmacology