Subchronic treatment of rats with nicotine: Interconversion of nicotinic receptor subtypes in brain

Luciana Romanelli, Birgitta Öhman, Abdu Adem, Agneta Nordberg

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

A significant increase in the number of cortical high-affinity (-)-[3H]nicotine binding sites was measured in rats treated with nicotine (0.45 mg/kg) twice daily for 18 days. Competition experiments with (-)-[3H]nicotine and various concentrations of unlabelled (-)-nicotine revealed that the proportion of high-affinity nicotine binding sites was significantly increased in the nicotine-treated group while the proportion of low-affinity nicotinic binding sites was similarly significantly reduced compared to the controls. In addition there was a significant decrease in the affinity of both subtypes of nicotinic binding sites.

Original languageEnglish
Pages (from-to)289-291
Number of pages3
JournalEuropean Journal of Pharmacology
Volume148
Issue number2
DOIs
Publication statusPublished - Mar 29 1988
Externally publishedYes

Keywords

  • (Subchronic treatment, Dependence, Rat)
  • Brain
  • Nicotinic receptor subtypes
  • [H]Nicotine

ASJC Scopus subject areas

  • Pharmacology

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