Successful overweight prevention in adolescents by increasing physical activity: A 4-year randomized controlled intervention

C. Simon, B. Schweitzer, M. Oujaa, A. Wagner, D. Arveiler, E. Triby, N. Copin, S. Blanc, C. Platat

Research output: Contribution to journalArticlepeer-review

134 Citations (Scopus)


Background: Population-based studies directed at promoting physical activity in youth have shown limited success in obesity prevention. Objective: To assess whether an intervention integrating environmental changes to induce sustained changes in physical activity, prevents overweight in adolescents. Design: Four-year randomized trial started in 2002 in eight middle schools of Eastern France. The intervention, randomized at school level, was designed to promote physical activity by changing attitudes through debates and attractive activities, and by providing social support and environmental changes encouraging physical activity. Subjects: Nine hundred and fifty four 12-year-old six-graders. Measurements: Body mass index (BMI), body composition, physical activity by questionnaire, plasma lipids and glucose, insulin resistance. Results: Intervention students had a lower increase in BMI (P=0.01) and age- and gender-adjusted BMI (P<0.02) over time than controls. The differences across groups of the age- and gender-adjusted BMI changes (95% confidence interval (CI)) were -0.29 (-0.51; -0.07) kg/m2 at 3 years, -0.25 (-0.51; 0.01) kg/m2 at 4 years. An interaction with baseline weight status was noted. The intervention had a significant effect throughout the study in initially non-overweight adolescents (-0.36 (-0.60;-0.11) kg/m2 for adjusted BMI at 4 years), corresponding to a lower increase in fat mass index (P<0.001). In initially overweight adolescents, the differences observed across groups at 2 years (-0.40 (-0.94; 0.13) kg/m2 for adjusted BMI) did not persist over time. At 4 years, 4.2% of the initially non-overweight adolescents were overweight in the intervention schools, 9.8% in the controls (odds ratio=0.41 (0.22; 0.75); P<0.01). Independent of initial weight status, compared with controls, intervention adolescents had an increase in supervised physical activity (P<0.0001), a decrease of TV/video viewing (P<0.01) and an increase of high-density cholesterol concentrations (P<0.0001). Conclusion: Enhancing physical activity with a multilevel program prevents excessive weight gain in non-overweight adolescents. Our study provides evidence that prevention of obesity in youth is feasible.

Original languageEnglish
Pages (from-to)1489-1498
Number of pages10
JournalInternational Journal of Obesity
Issue number10
Publication statusPublished - Oct 2008
Externally publishedYes


  • Adolescent
  • Cardiovascular risk
  • Physical activity
  • Randomized controlled program

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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