TY - JOUR
T1 - Sucralfate Overcomes Adverse Effect of Cigarette Smoking on Duodenal Ulcer Healing and Prolongs Subsequent Remission
AU - Lam, S. K.
AU - Hui, W. M.
AU - Lau, W. Y.
AU - Jaranicki, F.
AU - Lai, C. L.
AU - Lok, A. S.F.
AU - Ng, M. M.T.
AU - Fok, P. J.
AU - Poon, G. P.
AU - Choi, T. K.
N1 - Funding Information:
Received July 10, 1986. Accepted November 17, 1986. Address requests for reprints to: Professor S. K. Lam, M. D., Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong. This study was supported by the Peptic Ulcer Research Fund (311/041/0372) and by grants from the University of Hong Kong (311/030/8009/31, 311/030/8010/12, 335/041/0006, and 311/030/8010/69). The authors thank M. Chong, W. Y. Lee, S. Li, and P. Choi for nursing assistance, and G. H. Joe and P. Yip for technical assistance.
PY - 1987
Y1 - 1987
N2 - A unicenter, single-blind, randomized study was conducted on 283 patients with active duodenal ulcer to compare possible factors that may affect healing and relapse in patients treated with a potent antisecretory agent, cimetidine, or a site-protective and cytoprotective agent, sucral f ate. The endoscopic healing rates at 4 wk were 76% and 79%, respectively, and cross-over treatment of the failures for a further 4 wk resulted in 68% healing with cimetidine and 69% healing with sucral f ate, both differences being not statistically different. Unlike cimetidine, healing by sucral f ate was unaffected by cigarette smoking, reluctance to give up smoking, habitual use of alcohol, high maximal acid output, and large ulcer diameter. In particular, the healing rate of smokers treated with sucral f ate (82%) was significantly greater than that of smokers treated with cimetidine (63%). Duodenal bulb deformity significantly affected healing in both groups, and was the only offsetting factor identifiable for sucralfate out of 46 factors examined. 0 f the patients with healed ulcers, 238 participated in a 24-mo follow-up study consisting of interviews at 2-mo intervals and endoscopy at 4-mo intervals or whenever symptoms recurred. The cumulative relapse rate was significantly (p < 0.007) greater in patients healed with cimetidine than with sucral f ate, 50% relapse occurring at 6 and 12 mo, respectively. In both, the cumulative relapse rate was significantly greater in cigarette smokers than in nonsmokers, but smokers and nonsmokers treated with cimetidine relapsed (50% at 4 and 8 mo, repsectively) faster than the corresponding smokers and nonsmokers treated with sucral f ate (50% at 8 and 18 mo, respectively). Furthermore, in cimetidine- but not sucral f atehealed patients, early ulcer relapse (within 6 mo) was associated with short duration of illness, short remission period, long symptomatic spell, and reluctance to give up smoking. We conclude that smoking adversely affects duodenal ulcer healing by cimetidine and hastens subsequent relapse, and that sucral f ate overcomes the adverse effect of smoking on healing ' as encountered with cimetidine, and results in a subsequent remission period double that of cimetidine.
AB - A unicenter, single-blind, randomized study was conducted on 283 patients with active duodenal ulcer to compare possible factors that may affect healing and relapse in patients treated with a potent antisecretory agent, cimetidine, or a site-protective and cytoprotective agent, sucral f ate. The endoscopic healing rates at 4 wk were 76% and 79%, respectively, and cross-over treatment of the failures for a further 4 wk resulted in 68% healing with cimetidine and 69% healing with sucral f ate, both differences being not statistically different. Unlike cimetidine, healing by sucral f ate was unaffected by cigarette smoking, reluctance to give up smoking, habitual use of alcohol, high maximal acid output, and large ulcer diameter. In particular, the healing rate of smokers treated with sucral f ate (82%) was significantly greater than that of smokers treated with cimetidine (63%). Duodenal bulb deformity significantly affected healing in both groups, and was the only offsetting factor identifiable for sucralfate out of 46 factors examined. 0 f the patients with healed ulcers, 238 participated in a 24-mo follow-up study consisting of interviews at 2-mo intervals and endoscopy at 4-mo intervals or whenever symptoms recurred. The cumulative relapse rate was significantly (p < 0.007) greater in patients healed with cimetidine than with sucral f ate, 50% relapse occurring at 6 and 12 mo, respectively. In both, the cumulative relapse rate was significantly greater in cigarette smokers than in nonsmokers, but smokers and nonsmokers treated with cimetidine relapsed (50% at 4 and 8 mo, repsectively) faster than the corresponding smokers and nonsmokers treated with sucral f ate (50% at 8 and 18 mo, respectively). Furthermore, in cimetidine- but not sucral f atehealed patients, early ulcer relapse (within 6 mo) was associated with short duration of illness, short remission period, long symptomatic spell, and reluctance to give up smoking. We conclude that smoking adversely affects duodenal ulcer healing by cimetidine and hastens subsequent relapse, and that sucral f ate overcomes the adverse effect of smoking on healing ' as encountered with cimetidine, and results in a subsequent remission period double that of cimetidine.
KW - D
KW - MAO
KW - dose required for half maximal acid output and corrected for basal acid output
KW - maximal acid output
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U2 - 10.1016/S0016-5085(87)91077-8
DO - 10.1016/S0016-5085(87)91077-8
M3 - Article
C2 - 3557014
AN - SCOPUS:0023121409
SN - 0016-5085
VL - 92
SP - 1193
EP - 1201
JO - Gastroenterology
JF - Gastroenterology
IS - 5
ER -