Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii) complexes

Ahmed M. Mansour; Krzysztof Radacki; Ola R. Shehab

doi:10.1039/d1dt00979f

Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii) complexes

Ahmed M. Mansour, Krzysztof Radacki, Ola R. Shehab

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(η⁵-C₅Me₅)L](CF₃SO₃) gives rise to a water-soluble complex, which can bind to the model protein lysozymevianon-covalent interactions. The complex shows selective moderate toxicity againstCryptococcus neoformans(MIC = 21.6-43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells.

Original language	English
Pages (from-to)	10701-10706
Number of pages	6
Journal	Dalton Transactions
Volume	50
Issue number	31
DOIs	https://doi.org/10.1039/d1dt00979f
Publication status	Published - Aug 21 2021
Externally published	Yes

ASJC Scopus subject areas

Inorganic Chemistry

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abstract = "Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(η5-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozymevianon-covalent interactions. The complex shows selective moderate toxicity againstCryptococcus neoformans(MIC = 21.6-43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells.",

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T1 - Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii) complexes

AU - Mansour, Ahmed M.

AU - Radacki, Krzysztof

AU - Shehab, Ola R.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/8/21

Y1 - 2021/8/21

N2 - Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(η5-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozymevianon-covalent interactions. The complex shows selective moderate toxicity againstCryptococcus neoformans(MIC = 21.6-43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells.

AB - Introduction of the propyl-sulfonic acid group at N1 of the coordinated 2-(2-pyridyl)benzimidazole ligand (L) in [RhCl(η5-C5Me5)L](CF3SO3) gives rise to a water-soluble complex, which can bind to the model protein lysozymevianon-covalent interactions. The complex shows selective moderate toxicity againstCryptococcus neoformans(MIC = 21.6-43.3 μM) and exhibits no cytotoxicity to healthy HEK293 cells.

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SN - 1477-9226

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EP - 10706

JO - Dalton Transactions

JF - Dalton Transactions

IS - 31

ER -

Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(iii) complexes

Abstract

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