Sulfonylureas in the Current Practice of Type 2 Diabetes Management: Are They All the Same? Consensus from the Gulf Cooperation Council (GCC) Countries Advisory Board on Sulfonylureas

Yousef Al-Saleh, Shaun Sabico, Ahmed Al-Furqani, Amin Jayyousi, Dalal Alromaihi, Ebtesam Ba-Essa, Fatheya Alawadi, Juma Alkaabi, Mohamed Hassanein, Saud Al-Sifri, Seham Saleh, Thamer Alessa, Nasser M. Al-Daghri

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Since their inception in the commercial market in the mid-twentieth century, sulfonylureas (SUs) have remained a therapeutic option in the management of type 2 diabetes (T2D). Despite their established glucose-lowering effects, there is no consensus among global experts and modern guidelines regarding the priority of SUs in relation to other therapeutic options, given the lack of evidence that SUs are associated with a low risk of macrovascular events and excess mortality. However, findings from recent trials and real-time observations have resolved this contentious issue somewhat, albeit to varying degrees. The present consensus discusses the role of SUs in contemporary diabetes management in the Gulf Cooperation Council (GCC) countries. Regional experts from these countries gathered virtually to formulate a consensus following presentations of topics relevant to SU therapy with an emphasis on gliclazide, including long-term efficacy, cost, end-organ benefits, and side effects, based on up-to-date evidence. The present narrative review reflects the conclusions of this assembly and provides a platform upon which future guidelines for the use of SUs in the GCC can be tailored.

Original languageEnglish
Pages (from-to)2115-2132
Number of pages18
JournalDiabetes Therapy
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Gliclazide
  • Middle East
  • Sulfonylurea
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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