Supplemental ferulic acid does not affect metabolic markers and improves some oxidative damage parameters in diabetic rats

Serene Hilary, Ozaz Mohamed, Carine Platat, Muhammad A. Qureshi, Jaleel Kizhakkayil, Fatima Al-Meqbaali, Frank C. Howarth

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study investigated the differences in health outcomes associated with ferulic acid (FA) supplementation in animals before the induction of diabetes with streptozotocin (STZ) treatment and post-STZ treatment. 18 male Wistar rats were equally distributed into three groups: groups 1 and 2 received FA (50 mg/kg body weight) supplementation one week before STZ treatment (60 mg/kg body weight, intraperitoneal) and one week after STZ treatment, respectively; group 3 received STZ without FA supplementation. FA supplementation was continued for 12 weeks after STZ treatment. The results indicated no difference in glucose and lipid profile with FA supplementation. However, FA supplementation reduced lipid and protein oxidative damage in the heart, liver and pancreas and increased glutathione in the pancreas. The results indicate that while oxidative damages were positively affected by FA, it was not sufficient to improve metabolic markers of diabetes.

Original languageEnglish
Article numbere17313
JournalHeliyon
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Antioxidants
  • Diabetes
  • Ferulic acid
  • Oxidative stress
  • Polyphenols
  • Streptozotocin

ASJC Scopus subject areas

  • General

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