SUPPRESSION OF PANCREATIC ENDOCRINE TUMOUR SECRETION BY LONG-ACTING SOMATOSTATIN ANALOGUE

R. G. Long; T. E. Adrian; M. R. Brown; J. E. Rivier; A. J. Barnes; C. N. Mallinson; W. Vale; N. D. Christofides; S. R. Bloom

doi:10.1016/S0140-6736(79)92115-9

SUPPRESSION OF PANCREATIC ENDOCRINE TUMOUR SECRETION BY LONG-ACTING SOMATOSTATIN ANALOGUE

R. G. Long, T. E. Adrian, M. R. Brown, J. E. Rivier, A. J. Barnes, C. N. Mallinson, W. Vale, N. D. Christofides, S. R. Bloom

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

A new long-acting octapeptide analogue of somatostatin, Des AA^{1,2,4,5,12,13} D Try⁸ somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are now warranted.

Original language	English
Pages (from-to)	764-767
Number of pages	4
Journal	The Lancet
Volume	314
Issue number	8146
DOIs	https://doi.org/10.1016/S0140-6736(79)92115-9
Publication status	Published - Oct 13 1979
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/S0140-6736(79)92115-9

Cite this

@article{45cac5e305e1412dbf82e017ab9e7615,

title = "SUPPRESSION OF PANCREATIC ENDOCRINE TUMOUR SECRETION BY LONG-ACTING SOMATOSTATIN ANALOGUE",

abstract = "A new long-acting octapeptide analogue of somatostatin, Des AA1,2,4,5,12,13 D Try8 somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are now warranted.",

author = "Long, {R. G.} and Adrian, {T. E.} and Brown, {M. R.} and Rivier, {J. E.} and Barnes, {A. J.} and Mallinson, {C. N.} and W. Vale and Christofides, {N. D.} and Bloom, {S. R.}",

year = "1979",

month = oct,

day = "13",

doi = "10.1016/S0140-6736(79)92115-9",

language = "English",

volume = "314",

pages = "764--767",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8146",

}

TY - JOUR

T1 - SUPPRESSION OF PANCREATIC ENDOCRINE TUMOUR SECRETION BY LONG-ACTING SOMATOSTATIN ANALOGUE

AU - Long, R. G.

AU - Adrian, T. E.

AU - Brown, M. R.

AU - Rivier, J. E.

AU - Barnes, A. J.

AU - Mallinson, C. N.

AU - Vale, W.

AU - Christofides, N. D.

AU - Bloom, S. R.

PY - 1979/10/13

Y1 - 1979/10/13

N2 - A new long-acting octapeptide analogue of somatostatin, Des AA1,2,4,5,12,13 D Try8 somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are now warranted.

AB - A new long-acting octapeptide analogue of somatostatin, Des AA1,2,4,5,12,13 D Try8 somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are now warranted.

UR - http://www.scopus.com/inward/record.url?scp=0018673126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018673126&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(79)92115-9

DO - 10.1016/S0140-6736(79)92115-9

M3 - Article

C2 - 90860

AN - SCOPUS:0018673126

SN - 0140-6736

VL - 314

SP - 764

EP - 767

JO - The Lancet

JF - The Lancet

IS - 8146

ER -

SUPPRESSION OF PANCREATIC ENDOCRINE TUMOUR SECRETION BY LONG-ACTING SOMATOSTATIN ANALOGUE

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this