Surviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician

Simon Oczkowski, Fayez Alshamsi, Emilie Belley-Cote, John E. Centofanti, Morten Hylander Moller, Mark E. Nunnaly, Waleed Alhazzani

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The 2021 Surviving Sepsis Campaign Guidelines provided evidence-based recommendations for adult patients with sepsis and septic shock. This iteration of the guidelines placed increased emphasis on a diverse, global perspective, as well as on the long-term sequelae of sepsis experienced by patients and their families. The guidelines encompassed the following sections: 1) screening and early treatment; 2) infection; 3) hemodynamic management; 4) ventilation; 5) additional therapies; and 6) goals of care and long-term outcomes. In this review, we provide a summary of key recommendations of interest to the practicing clinician, which are either novel or require a change in practice, as well as those for which the evidence has substantially evolved in the 5 years since the 2016 iteration of the Guidelines. Rather than reviewing the underlying evidence, we emphasize the practical aspects of interpretation, dissemination, and implementation of these recommendations in the clinical setting.

Original languageEnglish
Article number16290
JournalPolish Archives of Internal Medicine
Issue number7-8
Publication statusPublished - Aug 22 2022


  • critical care
  • guidelines
  • infection
  • intensive care
  • sepsis

ASJC Scopus subject areas

  • Internal Medicine


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