TY - JOUR
T1 - Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate
AU - Galadari, Hassan
AU - Bishop, Alyssa G.
AU - Venna, Suraj S.
AU - Sultan, Emad
AU - Do, Daihung
AU - Zeltser, Ross
PY - 2009/7
Y1 - 2009/7
N2 - Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.
AB - Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.
UR - http://www.scopus.com/inward/record.url?scp=66949162308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66949162308&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2008.10.046
DO - 10.1016/j.jaad.2008.10.046
M3 - Article
C2 - 19539848
AN - SCOPUS:66949162308
SN - 0190-9622
VL - 61
SP - 123
EP - 125
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -