Abstract
Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.
Original language | English |
---|---|
Pages (from-to) | 285-290 |
Number of pages | 6 |
Journal | Heterocyclic Communications |
Volume | 21 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 1 2015 |
Keywords
- NMR
- anti-proliferation
- pyridine galactoside
- synthesis
ASJC Scopus subject areas
- Organic Chemistry