Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

Shaikha S. Alneyadi, Ihsan A. Shehadi, Ibrahim M. Abdou

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalHeterocyclic Communications
Volume21
Issue number5
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • NMR
  • anti-proliferation
  • pyridine galactoside
  • synthesis

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues'. Together they form a unique fingerprint.

Cite this