Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

Shaikha S. Alneyadi; Ihsan A. Shehadi; Ibrahim M. Abdou

doi:10.1515/hc-2015-0125

Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

Shaikha S. Alneyadi
, Ihsan A. Shehadi
, Ibrahim M. Abdou

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.

Original language	English
Pages (from-to)	285-290
Number of pages	6
Journal	Heterocyclic Communications
Volume	21
Issue number	5
DOIs	https://doi.org/10.1515/hc-2015-0125
Publication status	Published - Oct 1 2015

Keywords

NMR
anti-proliferation
pyridine galactoside
synthesis

ASJC Scopus subject areas

Organic Chemistry

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10.1515/hc-2015-0125

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title = "Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues",

abstract = "Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77\% at 100 μm) among the synthesized compounds.",

keywords = "NMR, anti-proliferation, pyridine galactoside, synthesis",

author = "Alneyadi, \{Shaikha S.\} and Shehadi, \{Ihsan A.\} and Abdou, \{Ibrahim M.\}",

note = "Publisher Copyright: {\textcopyright} 2015 by De Gruyter 2015.",

year = "2015",

month = oct,

day = "1",

doi = "10.1515/hc-2015-0125",

language = "English",

volume = "21",

pages = "285--290",

journal = "Heterocyclic Communications",

issn = "0793-0283",

publisher = "Walter de Gruyter GmbH",

number = "5",

}

TY - JOUR

T1 - Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

AU - Alneyadi, Shaikha S.

AU - Shehadi, Ihsan A.

AU - Abdou, Ibrahim M.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.

AB - Pyridine O-galactosides 3, 4, and 2-(4′-fluorobenzoyloxy)pyridine derivatives 5 were prepared by simple nucleophilic substitution reactions. These nucleosides were studied as anti-proliferating agents of human promyelotic leukemia (HL-60) cells. Compound 5a shows the highest anti-proliferative activity (77% at 100 μm) among the synthesized compounds.

KW - NMR

KW - anti-proliferation

KW - pyridine galactoside

KW - synthesis

UR - https://www.scopus.com/pages/publications/84944319985

UR - https://www.scopus.com/pages/publications/84944319985#tab=citedBy

U2 - 10.1515/hc-2015-0125

DO - 10.1515/hc-2015-0125

M3 - Article

AN - SCOPUS:84944319985

SN - 0793-0283

VL - 21

SP - 285

EP - 290

JO - Heterocyclic Communications

JF - Heterocyclic Communications

IS - 5

ER -

Synthesis and anti-proliferative activity of pyridine O-galactosides and 4-fluorobenzoyl analogues

Abstract

Keywords

ASJC Scopus subject areas

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