Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides

Ibrahim M. Abdou; Ayman M. Saleh; Hussein F. Zohdi

doi:10.3390/90300109

Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides

Ibrahim M. Abdou, Ayman M. Saleh, Hussein F. Zohdi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by ¹H and ¹³C-NMR spectroscopy. Glucoside 3b shows an in vitro IC₅₀ value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.

Original language	English
Pages (from-to)	109-116
Number of pages	8
Journal	Molecules
Volume	9
Issue number	3
DOIs	https://doi.org/10.3390/90300109
Publication status	Published - Mar 2004

Keywords

Antitumor agents
Glucopyranose
Trifluoromethylpyrazole

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/90300109

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abstract = "2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.",

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AU - Abdou, Ibrahim M.

AU - Saleh, Ayman M.

AU - Zohdi, Hussein F.

PY - 2004/3

Y1 - 2004/3

N2 - 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.

AB - 2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.

KW - Antitumor agents

KW - Glucopyranose

KW - Trifluoromethylpyrazole

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ER -

Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides

Abstract

Keywords

ASJC Scopus subject areas

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